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HSD3B2 recombinant protein :: 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS7016797 HSD3B2 recombinant protein
Unit / Price
0.01 mg  /  $1,180 +1 FREE 8GB USB
0.05 mg  /  $2,165 +2 FREE 8GB USB
0.1 mg  /  $3,370 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2), Recombinant Protein

 Also Known As   

Recombinant Human 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

 Product Gene Name   

HSD3B2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    HSDB3B [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-372
 Sequence    GWSCLVTGAG GLLGQRIVRL LVEEKELKEI RALDKAFRPE LREEFSKLQN RTKLTVLEGD ILDEPFLKRA CQDVSVVIHT ACIIDVFGVT HRESIMNVNV KGTQLLLEAC VQASVPVFIY TSSIEVAGPN SYKEIIQNGH EEEPLENTWP TPYPYSKKLA EKAVLAANGW NLKNGDTLYT CALRPTYIYG EGGPFLSASI NEALNNNGIL SSVGKFSTVN PVYVGNVAWA HILALRALRD PKKAPSVRGQ FYYISDDTPH QSYDNLNYIL SKEFGLRLDS RWSLPLTLMY WIGFLLEVVS FLLSPIYSYQ PPFNRHTVTL SNSVFTFSYK KAQRDLAYKP LYSWEEAKQK TVEWVGSLVD RHKETLKSKT Q
 OMIM    201810
 3D Structure    ModBase 3D Structure for P26439
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 Host    Cell Free Expression
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol.
 Tag Information    Tag type will be determined during the manufacturing process. Additional charge for tag removal. In most cases tags can be successfully removed. If the lab concludes the protein is no longer stable after tag removal then your protein will be supplied with the tag intact, and you will not be charged for tag removal service.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HSD3B2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for HSD3B2 recombinant protein    Transmembrane Protein
 Application Notes for HSD3B2 recombinant protein    This is a recombinant transmembrane protein expressed in a cell-free expression system.
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NCBI/Uniprot data below describe general gene information for HSD3B2. It may not necessarily be applicable to this product.
 NCBI GI #    4504509
 NCBI GeneID    3284
 NCBI Accession #    NP_000189.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000198.3 [Other Products]
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 UniProt Primary Accession #    P26439 [Other Products]
 UniProt Secondary Accession #    Q16010; Q53GD4; Q6AI10; Q6LDB9; Q99890; Q9UD08; A2RRA5 [Other Products]
 UniProt Related Accession #    P26439 [Other Products]
 Molecular Weight    24,987 Da
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 NCBI Official Full Name    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
 NCBI Official Synonym Full Names    hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
 NCBI Official Symbol    HSD3B2 [Similar Products]
 NCBI Official Synonym Symbols   
HSDB; HSD3B; SDR11E2
[Similar Products]
 NCBI Protein Information    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
 UniProt Protein Name    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
 UniProt Synonym Protein Names   
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II; 3-beta-HSD adrenal and gonadal typeIncluding the following 2 domains:3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.145)Alternative name(s):3-beta-hydroxy-5-ene steroid dehydrogenase; Progesterone reductase
 Protein Family    3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase
 UniProt Gene Name    HSD3B2 [Similar Products]
 UniProt Synonym Gene Names    HSDB3B; 3-beta-HSD II [Similar Products]
 UniProt Entry Name    3BHS2_HUMAN
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 NCBI Summary for HSD3B2    The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for HSD3B2    HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.

Protein type: Lipid Metabolism - C21-steroid hormone; EC 1.1.1.145; Endoplasmic reticulum; Mitochondrial; Membrane protein, integral; Oxidoreductase; Lipid Metabolism - androgen and estrogen; Isomerase; EC 5.3.3.1

Chromosomal Location of Human Ortholog: 1p13.1

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; integral to membrane; mitochondrial inner membrane; mitochondrial intermembrane space; mitochondrial membrane; smooth endoplasmic reticulum membrane

Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; steroid delta-isomerase activity

Biological Process: androgen biosynthetic process; glucocorticoid biosynthetic process; mineralocorticoid biosynthetic process; steroid biosynthetic process

Disease: 3-beta-hydroxysteroid Dehydrogenase, Type Ii, Deficiency Of
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 Research Articles on HSD3B2    1. HSD3B1 is involved in aldosterone production, despite its lower levels of expression compared with HSD3B2, and also possibly associated with KCNJ5 mutation in aldosterone-producing adenoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with HSD3B2 recombinant proteinPathways associated with HSD3B2 recombinant protein
 Reference Product  PubMed Publications
 CYP17A1 recombinant protein  >57 publications with HSD3B2 and CYP17A1
 CYP11A1 recombinant protein  >54 publications with HSD3B2 and CYP11A1
 CYP11B1 recombinant protein  >26 publications with HSD3B2 and CYP11B1
 CYP19A1 recombinant protein  >26 publications with HSD3B2 and CYP19A1
 CYP11B2 recombinant protein  >23 publications with HSD3B2 and CYP11B2
 SRD5A1 recombinant protein  >11 publications with HSD3B2 and SRD5A1
 HSD17B3 recombinant protein  >9 publications with HSD3B2 and HSD17B3
 CYP7B1 recombinant protein  >2 publications with HSD3B2 and CYP7B1
 CYP7A1 recombinant protein  >2 publications with HSD3B2 and CYP7A1
 HSD17B6 recombinant protein  >1 publications with HSD3B2 and HSD17B6
 Products by Pathway  Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Aldosterone Synthesis And Secretion Pathway antibodies  Aldosterone Synthesis And Secretion Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway antibodies  C19/C18-Steroid Hormone Biosynthesis, Pregnenolone => Androstenedione => Estrone Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Glucocorticoid & Mineralcorticoid Metabolism Pathway antibodies  Glucocorticoid & Mineralcorticoid Metabolism Pathway Diagram
 Glucocorticoid Biosynthesis Pathway antibodies  Glucocorticoid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
Diseases associated with HSD3B2 recombinant proteinOrgans/Tissues associated with HSD3B2 recombinant protein
 Disease Name  Pubmed Publications
 Hyperplasia Antibodies  >34 publications with HSD3B2 and Hyperplasia
 Adrenal Hyperplasia, Congenital Antibodies  >31 publications with HSD3B2 and Adrenal Hyperplasia, Congenital
 Prostatic Neoplasms Antibodies  >15 publications with HSD3B2 and Prostatic Neoplasms
 Polycystic Ovary Syndrome Antibodies  >8 publications with HSD3B2 and Polycystic Ovary Syndrome
 Hypertension Antibodies  >7 publications with HSD3B2 and Hypertension
 Obesity Antibodies  >5 publications with HSD3B2 and Obesity
 Breast Neoplasms Antibodies  >5 publications with HSD3B2 and Breast Neoplasms
 Necrosis Antibodies  >4 publications with HSD3B2 and Necrosis
 Infertility, Male Antibodies  >4 publications with HSD3B2 and Infertility, Male
 Hypospadias Antibodies  >4 publications with HSD3B2 and Hypospadias
 Organ/Tissue Name  Pubmed Publications
 Adrenal Gland Antibodies  >55 publications with HSD3B2 and Adrenal Gland
 Ovary Antibodies  >35 publications with HSD3B2 and Ovary
 Placenta Antibodies  >10 publications with HSD3B2 and Placenta
 Brain Antibodies  >7 publications with HSD3B2 and Brain
 Thymus Antibodies  >1 publications with HSD3B2 and Thymus
 Uncharacterized Tissue Antibodies  >1 publications with HSD3B2 and Uncharacterized Tissue
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