NP_694873.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2; 3-beta-HSD II; 3 beta-hydroxysteroid dehydrogenase 2; hydroxysteroid dehydrogenase-2, delta<5>-3-beta; 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II; 3-beta-HSD II
UniProt Synonym Gene Names
UniProt Entry Name
3BHS2_MOUSE
UniProt Comments for Hsd3b2
HSD3B2: protein localized to the nucleus in proliferating cells that seems to possess a tumor suppressor activity. Directly interacts with the RNA helicase eIF4A and inhibits protein synthesis by interfering with the assembly of the cap-dependent translation initiation complex. Suppresses carbonic anhydrase type II protein expression in carcinoid cell lines. Since tumor cells require a high bicarbonate flux for their growth, carbonic anhydrase suppression results in growth inhibition. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two differentially spliced isoforms have been identified.
Protein type: EC 1.1.1.145; Mitochondrial; Endoplasmic reticulum; Membrane protein, integral; Oxidoreductase; EC 5.3.3.1; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Isomerase
Cellular Component: membrane; mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; integral to membrane; mitochondrial intermembrane space
Molecular Function: steroid delta-isomerase activity; 3-beta-hydroxy-delta5-steroid dehydrogenase activity; oxidoreductase activity; isomerase activity; catalytic activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process: metabolic process; steroid biosynthetic process
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Pathways associated with Hsd3b2 recombinant protein
Diseases associated with Hsd3b2 recombinant protein
Organs/Tissues associated with Hsd3b2 recombinant protein
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