NP_036716.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
42,206 Da
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase type 5
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase type 5
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase type 5
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase type V; 3-beta-HSD V; 3-beta-hydroxy-5-ene steroid dehydrogenase; NADPH-dependent 3-beta-hydroxy-Delta(5)-steroid dehydrogenase (EC:1.1.1.-); Progesterone reductase
UniProt Synonym Gene Names
UniProt Entry Name
3BHS5_RAT
NCBI Summary for Hsd3b5
catalyzes the conversion of delta 5-3 beta-hydroxysteroids to delta 4-3-ketosteroids in steroid hormone biosynthesis [RGD, Feb 2006]
UniProt Comments for Hsd3b5
HSD3B5: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD V can only catalyze the conversion of dihydrotestosterone to 5 alpha- androstanediol in the presence of the cofactor NADPH. Does not function as a isomerase. Belongs to the 3-beta-HSD family.
Protein type: Membrane protein, integral; Mitochondrial; Oxidoreductase; EC 1.1.1.-
Cellular Component: endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle; mitochondrial membrane
Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; NAD binding; steroid binding; steroid dehydrogenase activity
Biological Process: progesterone metabolic process; regulation of steroid biosynthetic process; steroid biosynthetic process
Research Articles on Hsd3b5
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Pathways associated with Hsd3b5 recombinant protein
Diseases associated with Hsd3b5 recombinant protein
Organs/Tissues associated with Hsd3b5 recombinant protein
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