NP_647545.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
37,781 Da
NCBI Official Full Name
3 beta-hydroxysteroid dehydrogenase type 7
NCBI Official Synonym Full Names
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
NCBI Official Synonym Symbols
NCBI Protein Information
3 beta-hydroxysteroid dehydrogenase type 7
UniProt Protein Name
3 beta-hydroxysteroid dehydrogenase type 7
UniProt Synonym Protein Names
3 beta-hydroxysteroid dehydrogenase type VII; 3-beta-HSD VII; 3-beta-hydroxy-Delta(5)-C27 steroid oxidoreductase (EC:1.1.1.-); C(27) 3-beta-HSD; Cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase (EC:1.1.1.181); Confluent 3Y1 cell-associated 2
UniProt Synonym Gene Names
UniProt Entry Name
3BHS7_RAT
NCBI Summary for Hsd3b7
protein that is expressed in under growth-arrest conditions [RGD, Feb 2006]
UniProt Comments for Hsd3b7
HSD3B7: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Defects in HSD3B7 are the cause of congenital bile acid synthesis defect type 1 (CBAS1); also known as neonatal progressive intrahepatic cholestasis. CBAS1 is due to a primary defect in bile synthesis leading to progressive liver disease. Clinical features include neonatal jaundice, severe intrahepatic cholestasis and cirrhosis. Belongs to the 3-beta-HSD family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase; Membrane protein, multi-pass; EC 1.1.1.181
Cellular Component: endoplasmic reticulum membrane; integral to membrane; intracellular membrane-bound organelle
Molecular Function: 3-beta-hydroxy-delta5-steroid dehydrogenase activity; cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity; isomerase activity
Biological Process: bile acid metabolic process; cholesterol catabolic process; regulation of cell growth; steroid biosynthetic process
Research Articles on Hsd3b7
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Pathways associated with Hsd3b7 recombinant protein
Diseases associated with Hsd3b7 recombinant protein
Organs/Tissues associated with Hsd3b7 recombinant protein
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