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Hmgcr recombinant protein :: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1052425 Hmgcr recombinant protein
Unit / Price
1 mg (E-Coli)  /  $2,950 +3 FREE 8GB USB
1 mg (Yeast)  /  $3,405 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), Recombinant Protein

 Also Known As   

Recombinant Cricetulus griseus 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

 Product Synonym Names    Recombinant 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase EC= 1.1.1.34
 Product Gene Name   

Hmgcr recombinant protein

[Similar Products]
 Product Synonym Gene Name    HMGCR [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-887
 Sequence    MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTTEHSKVS LGLDEDVSKR IEPSVSLWQF YLSKMISMDI EQVVTLSLAF LLAVKYIFFE QAETESTLSL KNPITSPVVT PKKAPDNCCR REPLLVRRSE KLSSVEEEPG VSQDRKVEVI KPLVVETESA SRATFVLGAS GTSPPVAART QELEIELPSE PRPNEECLQI LESAEKGAKF LSDAEIIQLV NAKHIPAYKL ETLMETHERG VSIRRQLLST KLPEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA GPLCLDGKEY QVPMATTEGC LVASTNRGCR AIGLGGGASS RVLADGMTRG PVVRLPRACD SAEVKAWLET PEGFAVIKDA FDSTSRFARL QKLHVTMAGR NLYIRFQSKT GDAMGMNMIS KGTEKALLKL QEFFPEMQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL KTTTEAMIDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKSA
 Chromosome Location    chromosome: Un
 3D Structure    ModBase 3D Structure for P00347
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hmgcr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Hmgcr. It may not necessarily be applicable to this product.
 NCBI GI #    354491796
 NCBI GeneID    100756363
 NCBI Accession #    XP_003508040.1 [Other Products]
 NCBI GenBank Nucleotide #    XM_003507992.1 [Other Products]
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 UniProt Primary Accession #    P00347 [Other Products]
 UniProt Related Accession #    P00347 [Other Products]
 Molecular Weight    97,081 Da [Similar Products]
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 NCBI Official Full Name    PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase-like
 NCBI Official Symbol    Hmgcr [Similar Products]
 NCBI Protein Information    3-hydroxy-3-methylglutaryl-Coenzyme A reductase; HMG-CoA reductase
 UniProt Protein Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Gene Name    HMGCR [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA reductase [Similar Products]
 UniProt Entry Name    HMDH_CRIGR
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 UniProt Comments for Hmgcr    Function: Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins

By similarity.

Catalytic activity: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Enzyme regulation: Regulated by a negative feedback mechanism through sterols and non-sterol metabolites derived from mevalonate.

Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Subunit structure: Homodimer

By similarity. Interacts (via its SSD) with INSIG1; the interaction, accelerated by sterols, leads to the recruitment of HMGCR to AMFR/gp78 for its ubiquitination by the sterol-mediated ERAD pathway. Ref.7

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Post-translational modification: N-glycosylated. Glycosylated with high mannose chains including Man6(GlcNAc)2, Man7(GlcNAc)2 and Man8(GlcNAc)2. Deglycosylated by NGLY1 on release from the endoplasmic reticulum (ER) in a sterol-mediated manner

By similarity. Ref.2Undergoes sterol-mediated ubiquitination and ER-association degradation (ERAD). Accumulation of sterols in the endoplasmic reticulum (ER) membrane, triggers binding of the reductase to the ER membrane protein INSIG1. This INSIG1 binding leads to the recruitment of the ubiquitin ligase, AMFR/gp78, initiating ubiquitination of the reductase. The ubiquitinated reductase is then extracted from the ER membrane and delivered to cytosolic 26S proteosomes by a mechanism probably mediated by the ATPase Valosin-containing protein VCP/p97. Lys-248 is the main site of ubiquitination. Ubiquitination is enhanced by the presence of a geranylgeranylated protein.

Sequence similarities: Belongs to the HMG-CoA reductase family.Contains 1 SSD (sterol-sensing) domain.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with Hmgcr recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >44 publications with Hmgcr and Cardiovascular Diseases
 Neoplasms Antibodies  >41 publications with Hmgcr and Neoplasms
 Dyslipidemias Antibodies  >34 publications with Hmgcr and Dyslipidemias
 Fatty Liver Antibodies  >33 publications with Hmgcr and Fatty Liver
 Atherosclerosis Antibodies  >33 publications with Hmgcr and Atherosclerosis
 Hypercholesterolemia Antibodies  >32 publications with Hmgcr and Hypercholesterolemia
 Hyperlipidemias Antibodies  >29 publications with Hmgcr and Hyperlipidemias
 Nervous System Diseases Antibodies  >28 publications with Hmgcr and Nervous System Diseases
 Liver Diseases Antibodies  >24 publications with Hmgcr and Liver Diseases
 Heart Diseases Antibodies  >22 publications with Hmgcr and Heart Diseases
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