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Hmgcr recombinant protein :: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1262307 Hmgcr recombinant protein
Unit / Price
1 mg (E-Coli)  /  $2,950 +3 FREE 8GB USB
1 mg (Yeast)  /  $3,405 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), Recombinant Protein

 Also Known As   

Recombinant Rat 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) , partial

 Product Gene Name   

Hmgcr recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-887
 Sequence    MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTAEQSKVS LGLAEDVSKR IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QAETESTLSL KNPITSPVVT PKKAQDNCCR REPLLVRRNQ KLSSVEEDPG VNQDRKVEVI KPLVAEAETS GRATFVLGAS AASPPLALGA QEPGIELPSE PRPNEECLQI LESAEKGAKF LSDAEIIQLV NAKHIPAYKL ETLMETHERG VSIRRQLLSA KLAEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA GPLCLDGKEY QVPMATTEGC LVASTNRGCR AISLGGGASS RVLADGMSRG PVVRLPRACD SAEVKSWLET PEGFAVVKEA FDSTSRFARL QKLHVTLAGR NLYIRLQSKT GDAMGMNMIS KGTEKALLKL QEFFPELQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL KTTTEAMVDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKAA
 3D Structure    ModBase 3D Structure for P51639
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hmgcr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Hmgcr. It may not necessarily be applicable to this product.
 NCBI GI #    40538852
 NCBI GeneID    25675
 NCBI Accession #    NP_037266.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_013134.2 [Other Products]
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 UniProt Primary Accession #    P51639 [Other Products]
 UniProt Secondary Accession #    Q64601; Q6P2A6 [Other Products]
 UniProt Related Accession #    P51639 [Other Products]
 Molecular Weight    96,688 Da
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 NCBI Official Full Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA reductase
 NCBI Official Symbol    Hmgcr [Similar Products]
 NCBI Official Synonym Symbols   
3H3M
[Similar Products]
 NCBI Protein Information    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Protein Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Gene Name    Hmgcr [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA reductase [Similar Products]
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 NCBI Summary for Hmgcr    enzyme involved in mevalonate synthesis [RGD, Feb 2006]
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 UniProt Comments for Hmgcr    Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins.
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 Research Articles on Hmgcr    1. findings demonstrate for the first time that strain-dependent sex difference in serum Total Cholesterol level between F344 and SD rats is, at least in part, related to difference in the IL-1alpha-mediated HMGR gene expression level in the liver.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Hmgcr recombinant proteinPathways associated with Hmgcr recombinant protein
 Reference Product  PubMed Publications
 Srebf1 recombinant protein  >44 publications with Hmgcr and Srebf1
 Srebf2 recombinant protein  >41 publications with Hmgcr and Srebf2
 Hmgcs1 recombinant protein  >24 publications with Hmgcr and Hmgcs1
 Sqle recombinant protein  >10 publications with Hmgcr and Sqle
 Idi1 recombinant protein  >5 publications with Hmgcr and Idi1
 Mvk recombinant protein  >4 publications with Hmgcr and Mvk
 Rxra recombinant protein  >3 publications with Hmgcr and Rxra
 Hmgcs2 recombinant protein  >3 publications with Hmgcr and Hmgcs2
 Ppara recombinant protein  >2 publications with Hmgcr and Ppara
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Metabolism Pathway antibodies  Cholesterol Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
Diseases associated with Hmgcr recombinant proteinOrgans/Tissues associated with Hmgcr recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >79 publications with Hmgcr and Cardiovascular Diseases
 Fatty Liver Antibodies  >64 publications with Hmgcr and Fatty Liver
 Liver Diseases Antibodies  >56 publications with Hmgcr and Liver Diseases
 Atherosclerosis Antibodies  >51 publications with Hmgcr and Atherosclerosis
 Muscular Diseases Antibodies  >45 publications with Hmgcr and Muscular Diseases
 Necrosis Antibodies  >44 publications with Hmgcr and Necrosis
 Dyslipidemias Antibodies  >44 publications with Hmgcr and Dyslipidemias
 Hypercholesterolemia Antibodies  >43 publications with Hmgcr and Hypercholesterolemia
 Inflammation Antibodies  >42 publications with Hmgcr and Inflammation
 Autoimmune Diseases Antibodies  >40 publications with Hmgcr and Autoimmune Diseases
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >180 publications with Hmgcr and Liver
 Brain Antibodies  >40 publications with Hmgcr and Brain
 Kidney Antibodies  >21 publications with Hmgcr and Kidney
 Connective Tissue Antibodies  >21 publications with Hmgcr and Connective Tissue
 Lung Antibodies  >11 publications with Hmgcr and Lung
 Ovary Antibodies  >9 publications with Hmgcr and Ovary
 Prostate Antibodies  >7 publications with Hmgcr and Prostate
 Embryonic Tissue Antibodies  >5 publications with Hmgcr and Embryonic Tissue
 Eye Antibodies  >3 publications with Hmgcr and Eye
 Placenta Antibodies  >2 publications with Hmgcr and Placenta
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