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Hmgcr recombinant protein :: 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1262307 Hmgcr recombinant protein
Unit / Price
1 mg (E-Coli)  /  $2,950 +3 FREE 8GB USB
1 mg (Yeast)  /  $3,405 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr), Recombinant Protein

 Also Known As   

Recombinant Rat 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr)

 Product Synonym Names    Recombinant 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr); 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase EC= 1.1.1.34
 Product Gene Name   

Hmgcr recombinant protein

[Similar Products]
 Product Synonym Gene Name    Hmgcr [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-887
 Sequence    MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG VGTMSGVRQL EIMCCFGCMS VLANYFVFMT FFPACVSLVL ELSRESREGR PIWQLSHFAR VLEEEENKPN PVTQRVKMIM SLGLVLVHAH SRWIADPSPQ NSTAEQSKVS LGLAEDVSKR IEPSVSLWQF YLSKMISMDI EQVITLSLAL LLAVKYIFFE QAETESTLSL KNPITSPVVT PKKAQDNCCR REPLLVRRNQ KLSSVEEDPG VNQDRKVEVI KPLVAEAETS GRATFVLGAS AASPPLALGA QEPGIELPSE PRPNEECLQI LESAEKGAKF LSDAEIIQLV NAKHIPAYKL ETLMETHERG VSIRRQLLSA KLAEPSSLQY LPYRDYNYSL VMGACCENVI GYMPIPVGVA GPLCLDGKEY QVPMATTEGC LVASTNRGCR AISLGGGASS RVLADGMSRG PVVRLPRACD SAEVKSWLET PEGFAVVKEA FDSTSRFARL QKLHVTLAGR NLYIRLQSKT GDAMGMNMIS KGTEKALLKL QEFFPELQIL AVSGNYCTDK KPAAINWIEG RGKTVVCEAV IPAKVVREVL KTTTEAMVDV NINKNLVGSA MAGSIGGYNA HAANIVTAIY IACGQDAAQN VGSSNCITLM EASGPTNEDL YISCTMPSIE IGTVGGGTNL LPQQACLQML GVQGACKDNP GENARQLARI VCGTVMAGEL SLMAALAAGH LVRSHMVHNR SKINLQDLQG TCTKKAA
 Chromosome Location    Chromosome: 2; NC_005101.3 (46592883..46614276, complement). Location: 2q12
 3D Structure    ModBase 3D Structure for P51639
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hmgcr recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Hmgcr. It may not necessarily be applicable to this product.
 NCBI GI #    40538852
 NCBI GeneID    25675
 NCBI Accession #    NP_037266.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_013134.2 [Other Products]
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 UniProt Primary Accession #    P51639 [Other Products]
 UniProt Secondary Accession #    Q64601; Q6P2A6 [Other Products]
 UniProt Related Accession #    P51639 [Other Products]
 Molecular Weight    96,688 Da [Similar Products]
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 NCBI Official Full Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 NCBI Official Synonym Full Names    3-hydroxy-3-methylglutaryl-CoA reductase
 NCBI Official Symbol    Hmgcr [Similar Products]
 NCBI Official Synonym Symbols   
3H3M
[Similar Products]
 NCBI Protein Information    3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMG-CoA reductase
 UniProt Protein Name    3-hydroxy-3-methylglutaryl-coenzyme A reductase
 UniProt Gene Name    Hmgcr [Similar Products]
 UniProt Synonym Gene Names    HMG-CoA reductase [Similar Products]
 UniProt Entry Name    HMDH_RAT
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 NCBI Summary for Hmgcr    enzyme involved in mevalonate synthesis [RGD, Feb 2006]
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 UniProt Comments for Hmgcr    HMGCR: the rate-limiting enzyme for cholesterol synthesis. Regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by this reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis.

Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass; Motility/polarity/chemotaxis; EC 1.1.1.34; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Oxidoreductase

Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; intracellular membrane-bound organelle; endoplasmic reticulum; integral to membrane

Molecular Function: hydroxymethylglutaryl-CoA reductase (NADPH) activity; protein homodimerization activity; protein phosphatase 2A binding; hydroxymethylglutaryl-CoA reductase activity; coenzyme binding

Biological Process: farnesyl diphosphate biosynthetic process, mevalonate pathway; negative regulation of MAP kinase activity; isoprenoid biosynthetic process; positive regulation of smooth muscle cell proliferation; positive regulation of skeletal muscle development; cholesterol biosynthetic process; positive regulation of stress-activated MAPK cascade; coenzyme A metabolic process; myoblast differentiation; ubiquinone metabolic process; response to ethanol; negative regulation of vasodilation; positive regulation of cell proliferation; visual learning; protein tetramerization; response to nutrient; negative regulation of apoptosis; aging
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 Research Articles on Hmgcr    1. These findings indicate a role for TTP in the insulin-mediated activation of hepatic HMGR transcription.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Hmgcr recombinant proteinDiseases associated with Hmgcr recombinant protein
 Products by Pathway  Pathway Diagram
 Activation Of Gene Expression By SREBP (SREBF) Pathway antibodies  Activation Of Gene Expression By SREBP (SREBF) Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 C5 Isoprenoid Biosynthesis, Mevalonate Pathway antibodies  C5 Isoprenoid Biosynthesis, Mevalonate Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Biosynthesis Pathway antibodies  Cholesterol Biosynthesis Pathway Diagram
 Cholesterol Metabolism Pathway antibodies  Cholesterol Metabolism Pathway Diagram
 Cholesterol Metabolism Pathway antibodies  Cholesterol Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >44 publications with Hmgcr and Cardiovascular Diseases
 Neoplasms Antibodies  >41 publications with Hmgcr and Neoplasms
 Dyslipidemias Antibodies  >34 publications with Hmgcr and Dyslipidemias
 Fatty Liver Antibodies  >33 publications with Hmgcr and Fatty Liver
 Atherosclerosis Antibodies  >33 publications with Hmgcr and Atherosclerosis
 Hypercholesterolemia Antibodies  >32 publications with Hmgcr and Hypercholesterolemia
 Hyperlipidemias Antibodies  >29 publications with Hmgcr and Hyperlipidemias
 Nervous System Diseases Antibodies  >28 publications with Hmgcr and Nervous System Diseases
 Liver Diseases Antibodies  >24 publications with Hmgcr and Liver Diseases
 Heart Diseases Antibodies  >22 publications with Hmgcr and Heart Diseases
Organs/Tissues associated with Hmgcr recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >125 publications with Hmgcr and Liver
 Brain Antibodies  >27 publications with Hmgcr and Brain
 Kidney Antibodies  >24 publications with Hmgcr and Kidney
 Ovary Antibodies  >14 publications with Hmgcr and Ovary
 Prostate Antibodies  >5 publications with Hmgcr and Prostate
 Lung Antibodies  >5 publications with Hmgcr and Lung
 Connective Tissue Antibodies  >3 publications with Hmgcr and Connective Tissue
 Embryonic Tissue Antibodies  >3 publications with Hmgcr and Embryonic Tissue
 Spleen Antibodies  >3 publications with Hmgcr and Spleen
 Eye Antibodies  >1 publications with Hmgcr and Eye
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