O08756.4
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
27,419 Da
NCBI Official Full Name
3-hydroxyacyl-CoA dehydrogenase type-2
NCBI Official Synonym Full Names
hydroxysteroid (17-beta) dehydrogenase 10
NCBI Protein Information
3-hydroxyacyl-CoA dehydrogenase type-2
UniProt Protein Name
3-hydroxyacyl-CoA dehydrogenase type-2
UniProt Synonym Protein Names
17-beta-hydroxysteroid dehydrogenase 10 (EC:1.1.1.51
UniProt Synonym Gene Names
UniProt Comments for Hsd17b10
Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone (). Catalyzes the third step in the beta-oxidation of fatty acids (). Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids (). Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids (). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (). Essential for structural and functional integrity of mitochondria (PubMed:20077426).
Research Articles on Hsd17b10
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Pathways associated with Hsd17b10 recombinant protein
Organs/Tissues associated with Hsd17b10 recombinant protein
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