NP_002026.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
29,159 Da
NCBI Official Full Name
3-ketodihydrosphingosine reductase
NCBI Official Synonym Full Names
3-ketodihydrosphingosine reductase
NCBI Protein Information
3-ketodihydrosphingosine reductase
UniProt Protein Name
3-ketodihydrosphingosine reductase
UniProt Synonym Protein Names
3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; Short chain dehydrogenase/reductase family 35C member 1
UniProt Synonym Gene Names
UniProt Entry Name
KDSR_HUMAN
NCBI Summary for KDSR
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for KDSR
FVT1: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Oxidoreductase; Lipid Metabolism - sphingolipid; Oncoprotein; EC 1.1.1.102; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q21.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; extracellular space; integral to membrane; membrane
Molecular Function: 3-dehydrosphinganine reductase activity
Biological Process: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process
Research Articles on KDSR
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Pathways associated with KDSR recombinant protein
Diseases associated with KDSR recombinant protein
Organs/Tissues associated with KDSR recombinant protein
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