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Srd5a1 recombinant protein :: 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS966376 Srd5a1 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1), Recombinant Protein

 Also Known As   

Recombinant Rat 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1)

 Product Synonym Names    Recombinant 3-oxo-5-alpha-steroid 4-dehydrogenase 1 (Srd5a1); 3-oxo-5-alpha-steroid 4-dehydrogenase 1 EC= 1.3.99.5; SR type 1 Steroid 5-alpha-reductase 1; S5AR 1
 Product Gene Name   

Srd5a1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Srd5a1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-259
 Sequence    MVPLMELDEL CLLDMLVYLE GFMAFVSIVG LRSVGSPYGR YSPQWPGIRV PARPAWFIQE LPSMAWPLYE YIRPAAARLG NLPNRVLLAM FLIHYVQRTL VFPVLIRGGK PTLLVTFVLA FLFCTFNGYV QSRYLSQFAV YAEDWVTHPC FLTGFALWLV GMVINIHSDH ILRNLRKPGE TGYKIPRGGL FEYVSAANYF GELVEWCGFA LASWSLQGVV FALFTLSTLL TRAKQHHQWY HEKFEDYPKS RKILIPFVL
 Chromosome Location    Chromosome: 1; NC_005100.3 (37717526..37751716). Location: 17p14
 3D Structure    ModBase 3D Structure for P24008
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Srd5a1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Srd5a1. It may not necessarily be applicable to this product.
 NCBI GI #    77404421
 NCBI GeneID    24950
 NCBI Accession #    NP_058766.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_017070.3 [Other Products]
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 UniProt Primary Accession #    P24008 [Other Products]
 UniProt Secondary Accession #    A0JPJ6 [Other Products]
 UniProt Related Accession #    P24008 [Other Products]
 Molecular Weight    29,780 Da [Similar Products]
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 NCBI Official Full Name    3-oxo-5-alpha-steroid 4-dehydrogenase 1
 NCBI Official Synonym Full Names    steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
 NCBI Official Symbol    Srd5a1 [Similar Products]
 NCBI Official Synonym Symbols   
S5AR 1
[Similar Products]
 NCBI Protein Information    3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; steroid 5 alpha-reductase 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1
 UniProt Protein Name    3-oxo-5-alpha-steroid 4-dehydrogenase 1
 UniProt Synonym Protein Names   
SR type 1; Steroid 5-alpha-reductase 1
 Protein Family    3-oxo-5-alpha-steroid 4-dehydrogenase
 UniProt Gene Name    Srd5a1 [Similar Products]
 UniProt Synonym Gene Names    S5AR 1 [Similar Products]
 UniProt Entry Name    S5A1_RAT
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 NCBI Summary for Srd5a1    catalyzes the conversion of testosterone to dihydrotestosterone; required for male sex differentiation [RGD, Feb 2006]
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 UniProt Comments for Srd5a1    Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.

Catalytic activity: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH.

Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein

Potential.

Tissue specificity: Liver and prostate (at a low level).

Developmental stage: After the establishment of chromosomal sex at fertilization.

Induction: Its expression is regulated by androgens such as testosterone.

Sequence similarities: Belongs to the steroid 5-alpha reductase family.

Biophysicochemical propertiespH dependence:Optimally active at alkaline pHs.
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 Research Articles on Srd5a1    1. Tesosterone concentrations during postnatal sexual differentiation of the rat central nervous system, among other sex-dependent factors, influence brain levels of 5alpha-Reductase isozymes in adulthood
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Srd5a1 recombinant proteinDiseases associated with Srd5a1 recombinant protein
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamins A And D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamins A And D Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >22 publications with Srd5a1 and Neoplasms
 Prostatic Neoplasms Antibodies  >14 publications with Srd5a1 and Prostatic Neoplasms
 Mental Disorders Antibodies  >5 publications with Srd5a1 and Mental Disorders
 Cardiovascular Diseases Antibodies  >4 publications with Srd5a1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >4 publications with Srd5a1 and Breast Neoplasms
 Hirsutism Antibodies  >4 publications with Srd5a1 and Hirsutism
 Carcinoma Antibodies  >3 publications with Srd5a1 and Carcinoma
 Neoplasms, Experimental Antibodies  >3 publications with Srd5a1 and Neoplasms, Experimental
 Prostatic Hyperplasia Antibodies  >3 publications with Srd5a1 and Prostatic Hyperplasia
 Hyperplasia Antibodies  >3 publications with Srd5a1 and Hyperplasia
Organs/Tissues associated with Srd5a1 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >20 publications with Srd5a1 and Prostate
 Brain Antibodies  >6 publications with Srd5a1 and Brain
 Ovary Antibodies  >5 publications with Srd5a1 and Ovary
 Liver Antibodies  >5 publications with Srd5a1 and Liver
 Embryonic Tissue Antibodies  >3 publications with Srd5a1 and Embryonic Tissue
 Kidney Antibodies  >1 publications with Srd5a1 and Kidney
 Lung Antibodies  >1 publications with Srd5a1 and Lung
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