NP_058766.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
NCBI Official Synonym Full Names
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
NCBI Official Synonym Symbols
NCBI Protein Information
3-oxo-5-alpha-steroid 4-dehydrogenase 1; SR type 1; steroid 5 alpha-reductase 1; steroid 5-alpha-reductase 1; steroid-5-alpha-reductase 1
UniProt Protein Name
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt Synonym Protein Names
SR type 1; Steroid 5-alpha-reductase 1
UniProt Synonym Gene Names
UniProt Entry Name
S5A1_RAT
NCBI Summary for Srd5a1
catalyzes the conversion of testosterone to dihydrotestosterone; required for male sex differentiation [RGD, Feb 2006]
UniProt Comments for Srd5a1
Function: Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Catalytic activity: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH.
Subcellular location: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein
Potential.
Tissue specificity: Liver and prostate (at a low level).
Developmental stage: After the establishment of chromosomal sex at fertilization.
Induction: Its expression is regulated by androgens such as testosterone.
Sequence similarities: Belongs to the steroid 5-alpha reductase family.
Biophysicochemical propertiespH dependence:Optimally active at alkaline pHs.
Research Articles on Srd5a1
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Pathways associated with Srd5a1 recombinant protein
Diseases associated with Srd5a1 recombinant protein
Organs/Tissues associated with Srd5a1 recombinant protein
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