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SRD5A2 recombinant protein :: 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS954548 SRD5A2 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $435 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $575 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $615 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $630 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $775 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $830 +1 FREE 8GB USB
1 mg (E-Coli)  /  $890 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $940 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $980 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,010 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,415 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,420 +1 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,550 +1 FREE 8GB USB
1 mg (Baculovirus)  /  $1,910 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2), Recombinant Protein

 Also Known As   

Recombinant Human 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)

 Product Synonym Names    Recombinant 3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2); 3-oxo-5-alpha-steroid 4-dehydrogenase 2 EC= 1.3.99.5; 5 alpha-SR2 SR type 2 Steroid 5-alpha-reductase 2; S5AR 2 Type II 5-alpha reductase
 Product Gene Name   

SRD5A2 recombinant protein

[Similar Products]
 Product Synonym Gene Name    SRD5A2 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    29-71. Partial.
 Sequence    KPSGYGKHTE SLKPAATRLP ARAAWFLQEL PSFAVPAGIL ARQ
 Chromosome Location    Chromosome: 2; NC_000002.11 (31749656..31806040, complement). Location: 2p23
 OMIM    264600
 3D Structure    ModBase 3D Structure for P31213
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of SRD5A2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for SRD5A2. It may not necessarily be applicable to this product.
 NCBI GI #    39812447
 NCBI GeneID    6716
 NCBI Accession #    NP_000339.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000348.3 [Other Products]
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 UniProt Primary Accession #    P31213 [Other Products]
 UniProt Secondary Accession #    Q2M1R4; Q9BYE6; B2RE87 [Other Products]
 UniProt Related Accession #    P31213 [Other Products]
 Molecular Weight    28,393 Da [Similar Products]
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 NCBI Official Full Name    3-oxo-5-alpha-steroid 4-dehydrogenase 2
 NCBI Official Synonym Full Names    steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2)
 NCBI Official Symbol    SRD5A2 [Similar Products]
 NCBI Protein Information    3-oxo-5-alpha-steroid 4-dehydrogenase 2; S5AR 2; SR type 2; 5 alpha-SR2; type II 5-alpha reductase; steroid 5-alpha-reductase 2
 UniProt Protein Name    3-oxo-5-alpha-steroid 4-dehydrogenase 2
 UniProt Synonym Protein Names   
5 alpha-SR2; SR type 2; Steroid 5-alpha-reductase 2; S5AR 2; Type II 5-alpha reductase
 Protein Family    3-oxo-5-alpha-steroid 4-dehydrogenase
 UniProt Gene Name    SRD5A2 [Similar Products]
 UniProt Synonym Gene Names    S5AR 2 [Similar Products]
 UniProt Entry Name    S5A2_HUMAN
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 NCBI Summary for SRD5A2    This gene encodes a microsomal protein expressed at high levels in androgen-sensitive tissues such as the prostate. The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. Deficiencies in this gene can result in male pseudohermaphroditism, specifically pseudovaginal perineoscrotal hypospadias (PPSH). [provided by RefSeq, Jul 2008]
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 UniProt Comments for SRD5A2    SRD5A2: Converts testosterone (T) into 5-alpha- dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology. Defects in SRD5A2 are the cause of pseudovaginal perineoscrotal hypospadias (PPSH). A form of male pseudohermaphroditism in which 46,XY males show ambiguous genitalia at birth, including perineal hypospadias and a blind perineal pouch, and develop masculinization at puberty. The name of the disorder stems from the finding of a blind-ending perineal opening resembling a vagina and a severely hypospadiac penis with the urethra opening onto the perineum. Belongs to the steroid 5-alpha reductase family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - androgen and estrogen; EC 1.3.1.22; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: endoplasmic reticulum membrane; cell soma; integral to membrane

Molecular Function: amide binding; cholestenone 5-alpha-reductase activity; sterol 5-alpha reductase activity; 3-oxo-5-alpha-steroid 4-dehydrogenase activity

Biological Process: steroid metabolic process; response to nutrient levels; response to drug; response to peptide hormone stimulus; hypothalamus development; dibenzo-p-dioxin metabolic process; male gonad development; phthalate metabolic process; androgen metabolic process; hippocampus development; response to testosterone stimulus; androgen biosynthetic process; female genitalia development; biphenyl metabolic process; cell-cell signaling; male genitalia development; cell differentiation; response to follicle-stimulating hormone stimulus; steroid catabolic process

Disease: Pseudovaginal Perineoscrotal Hypospadias
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 Research Articles on SRD5A2    1. The rs13395648 TC genotype was associated with a significantly lower semen volume compared with the TT genotype.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with SRD5A2 recombinant proteinDiseases associated with SRD5A2 recombinant protein
 Products by Pathway  Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamins A And D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamins A And D Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Androgen Biosynthesis Pathway antibodies  Androgen Biosynthesis Pathway Diagram
 Disease Name  Pubmed Publications
 Genital Diseases, Male Antibodies  >419 publications with SRD5A2 and Genital Diseases, Male
 Neoplasms Antibodies  >336 publications with SRD5A2 and Neoplasms
 Congenital Abnormalities Antibodies  >254 publications with SRD5A2 and Congenital Abnormalities
 Prostatic Neoplasms Antibodies  >246 publications with SRD5A2 and Prostatic Neoplasms
 Disorders of Sex Development Antibodies  >230 publications with SRD5A2 and Disorders of Sex Development
 Hyperplasia Antibodies  >229 publications with SRD5A2 and Hyperplasia
 Mental Disorders Antibodies  >208 publications with SRD5A2 and Mental Disorders
 Prostatic Hyperplasia Antibodies  >202 publications with SRD5A2 and Prostatic Hyperplasia
 Hirsutism Antibodies  >50 publications with SRD5A2 and Hirsutism
 Alopecia Antibodies  >46 publications with SRD5A2 and Alopecia
Organs/Tissues associated with SRD5A2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >529 publications with SRD5A2 and Prostate
 Brain Antibodies  >219 publications with SRD5A2 and Brain
 Skin Antibodies  >202 publications with SRD5A2 and Skin
 Testis Antibodies  >158 publications with SRD5A2 and Testis
 Liver Antibodies  >154 publications with SRD5A2 and Liver
 Kidney Antibodies  >33 publications with SRD5A2 and Kidney
 Uterus Antibodies  >32 publications with SRD5A2 and Uterus
 Lung Antibodies  >11 publications with SRD5A2 and Lung
 Eye Antibodies  >10 publications with SRD5A2 and Eye
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