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AKR1D1 recombinant protein :: 3-oxo-5-beta-steroid 4-dehydrogenase (AKR1D1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS953236 AKR1D1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $735 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $985 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $990 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,080 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,150 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,240 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,255 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,300 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,535 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,810 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,875 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,980 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,405 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

3-oxo-5-beta-steroid 4-dehydrogenase (AKR1D1), Recombinant Protein

 Also Known As   

Recombinant Human 3-oxo-5-beta-steroid 4-dehydrogenase (AKR1D1)

 Product Gene Name   

AKR1D1 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-326aa, Full length protein
 Sequence    MDLSAASHRI PLSDGNSIPI IGLGTYSEPK STPKGACATS VKVAIDTGYR HIDGAYIYQN EHEVGEAIRE KIAEGKVRRE DIFYCGKLWA TNHVPEMVRP TLERTLRVLQ LDYVDLYIIE VPMAFKPGDE IYPRDENGKW LYHKSNLCAT WEAMEACKDA GLVKSLGVSN FNRRQLELIL NKPGLKHKPV SNQVECHPYF TQPKLLKFCQ QHDIVITAYS PLGTSRNPIW VNVSSPPLLK DALLNSLGKR YNKTAAQIVL RFNIQRGVVV IPKSFNLERI KENFQIFDFS LTEEEMKDIE ALNKNVRFVE LLMWRDHPEY PFHDEY
 OMIM    235555
 3D Structure    ModBase 3D Structure for P51857
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of AKR1D1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for AKR1D1 recombinant protein

   The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction.
NCBI/Uniprot data below describe general gene information for AKR1D1. It may not necessarily be applicable to this product.
 NCBI GI #    300116271
 NCBI GeneID    6718
 NCBI Accession #    NP_001177835.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001190906.1 [Other Products]
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 UniProt Primary Accession #    P51857 [Other Products]
 UniProt Secondary Accession #    A1L4P6; A8K060; B4DPN3; B4DPN8 [Other Products]
 UniProt Related Accession #    P51857 [Other Products]
 Molecular Weight    32,890 Da
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 NCBI Official Full Name    3-oxo-5-beta-steroid 4-dehydrogenase isoform 2
 NCBI Official Synonym Full Names    aldo-keto reductase family 1 member D1
 NCBI Official Symbol    AKR1D1 [Similar Products]
 NCBI Official Synonym Symbols   
CBAS2; SRD5B1; 3o5bred
[Similar Products]
 NCBI Protein Information    3-oxo-5-beta-steroid 4-dehydrogenase
 UniProt Protein Name    3-oxo-5-beta-steroid 4-dehydrogenase
 UniProt Synonym Protein Names   
Aldo-keto reductase family 1 member D1; Delta(4)-3-ketosteroid 5-beta-reductase; Delta(4)-3-oxosteroid 5-beta-reductase
 Protein Family    3-oxo-5-beta-steroid 4-dehydrogenase
 UniProt Gene Name    AKR1D1 [Similar Products]
 UniProt Synonym Gene Names    SRD5B1 [Similar Products]
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 NCBI Summary for AKR1D1    The enzyme encoded by this gene is responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure. Deficiency of this enzyme may contribute to hepatic dysfunction. Three transcript variants encoding different isoforms have been found for this gene. Other variants may be present, but their full-length natures have not been determined yet. [provided by RefSeq, Jul 2010]
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 UniProt Comments for AKR1D1    Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
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 Research Articles on AKR1D1    1. infant proved to be a compound heterozygote of the AKR1D1 variants c.579+2delT and c.853C>T(p.Q285X), two novel mutations originated from his mother and father, respectively
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with AKR1D1 recombinant proteinPathways associated with AKR1D1 recombinant protein
 Reference Product  PubMed Publications
 SRD5A2 recombinant protein  >5 publications with AKR1D1 and SRD5A2
 SRD5A1 recombinant protein  >3 publications with AKR1D1 and SRD5A1
 HSD17B6 recombinant protein  >1 publications with AKR1D1 and HSD17B6
 HSD17B2 recombinant protein  >1 publications with AKR1D1 and HSD17B2
 CYP8B1 recombinant protein  >1 publications with AKR1D1 and CYP8B1
 Products by Pathway  Pathway Diagram
 Bile Acid And Bile Salt Metabolism Pathway antibodies  Bile Acid And Bile Salt Metabolism Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway antibodies  Bile Acid Biosynthesis, Cholesterol => Cholate/chenodeoxycholate Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Primary Bile Acid Biosynthesis Pathway antibodies  Primary Bile Acid Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
 Steroid Hormone Biosynthesis Pathway antibodies  Steroid Hormone Biosynthesis Pathway Diagram
Diseases associated with AKR1D1 recombinant proteinOrgans/Tissues associated with AKR1D1 recombinant protein
 Disease Name  Pubmed Publications
 Cholestasis Antibodies  >7 publications with AKR1D1 and Cholestasis
 Liver Diseases Antibodies  >6 publications with AKR1D1 and Liver Diseases
 Hepatitis Antibodies  >2 publications with AKR1D1 and Hepatitis
 Fatty Liver Antibodies  >2 publications with AKR1D1 and Fatty Liver
 Mental Disorders Antibodies  >1 publications with AKR1D1 and Mental Disorders
 Inflammation Antibodies  >1 publications with AKR1D1 and Inflammation
 Hepatomegaly Antibodies  >1 publications with AKR1D1 and Hepatomegaly
 Hypertrophy Antibodies  >1 publications with AKR1D1 and Hypertrophy
 Hyperplasia Antibodies  >1 publications with AKR1D1 and Hyperplasia
 Hemochromatosis Antibodies  >1 publications with AKR1D1 and Hemochromatosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >18 publications with AKR1D1 and Liver
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