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4 1BBR recombinant protein :: 4-1BB Receptor Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS145211 4 1BBR recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.02 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $3,515 +4 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4-1BB Receptor (4 1BBR), Recombinant Protein

 Also Known As   

Recombinant Human 4-1BB Receptor His Tag

 Product Synonym Names    4 1BBR Human, His; 4-1BB Receptor Human Recombinant, His Tag; Tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor T-cell; antigen 4-1BB homolog; T-cell antigen ILA; CD137 antigen; CDw137; ILA; 4-1BB; MGC2172; 4-1BBR; TNFRSF9; 4 1BBR, His
 Product Gene Name   

4 1BBR recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    MGSSHHH HHH SSGLVPRGSH MGSMFE RTRS LQDPCSNCPA GTFCDNNRNQ ICSPCPPNSF SSAGGQRTCD ICRQCKGVFR TRKECSSTSN AECDCTPGFH CLGAGCSMCE QDCKQGQELT KKGCKDCCFG TFNDQKRGIC RPWTNCSLDG KSVLVNGTKE RDVVCGPSPA DLSPGASSVT PPAPAREPGH SPQ.
 OMIM    602250
 3D Structure    ModBase 3D Structure for Q07011
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 Host    E Coli
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE.
 Form/Format    4-1BBR protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.
Sterile Filtered clear solution.
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of 4 1BBR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for 4 1BBR recombinant protein

   Description: 4-1BBR Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 193 amino acids (18-186 a.a) and having a molecular mass of 20kDa.4-1BBR is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Introduction: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.
 Product Categories/Family for 4 1BBR recombinant protein    CYTOKINES AND GROWTH FACTORS; Cytokines
NCBI/Uniprot data below describe general gene information for 4 1BBR. It may not necessarily be applicable to this product.
 NCBI GI #    5730095
 NCBI GeneID    3604
 NCBI Accession #    NP_001552.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001561.5 [Other Products]
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 UniProt Primary Accession #    Q07011 [Other Products]
 UniProt Related Accession #    Q07011; AAB34924 [Other Products]
 Molecular Weight    27,899 Da
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 NCBI Official Full Name    tumor necrosis factor receptor superfamily member 9
 NCBI Official Synonym Full Names    tumor necrosis factor receptor superfamily, member 9
 NCBI Official Symbol    TNFRSF9 [Similar Products]
 NCBI Official Synonym Symbols   
ILA; 4-1BB; CD137; CDw137
[Similar Products]
 NCBI Protein Information    tumor necrosis factor receptor superfamily member 9; 4-1BB ligand receptor; CD137 antigen; T cell antigen ILA; T-cell antigen 4-1BB homolog; T-cell antigen ILA; homolog of mouse 4-1BB; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63; receptor protein 4-1BB
 UniProt Protein Name    Tumor necrosis factor receptor superfamily member 9
 UniProt Synonym Protein Names   
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137
 UniProt Gene Name    TNFRSF9 [Similar Products]
 UniProt Synonym Gene Names    CD137; ILA [Similar Products]
 UniProt Entry Name    TNR9_HUMAN
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 NCBI Summary for 4 1BBR    The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
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 UniProt Comments for 4 1BBR    TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 1p36

Cellular Component: extracellular space; integral to plasma membrane; external side of plasma membrane

Molecular Function: cytokine binding; receptor activity

Biological Process: negative regulation of cell proliferation; apoptosis
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 Research Articles on 4 1BBR    1. DENV C disrupts Daxx and NF-kappaB interaction to induce CD137-mediated apoptosis during DENV infection
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with 4 1BBR recombinant proteinPathways associated with 4 1BBR recombinant protein
 Reference Product  PubMed Publications
 TNFSF9 recombinant protein  >76 publications with 4 1BBR and TNFSF9
 TNFRSF4 recombinant protein  >40 publications with 4 1BBR and TNFRSF4
 TRAF2 recombinant protein  >15 publications with 4 1BBR and TRAF2
 IL2RA recombinant protein  >13 publications with 4 1BBR and IL2RA
 TRAF1 recombinant protein  >8 publications with 4 1BBR and TRAF1
 TRAF3 recombinant protein  >3 publications with 4 1BBR and TRAF3
 IL2RB recombinant protein  >2 publications with 4 1BBR and IL2RB
 IL2RG recombinant protein  >1 publications with 4 1BBR and IL2RG
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 TCR Signaling Pathway antibodies  TCR Signaling Pathway Diagram
Diseases associated with 4 1BBR recombinant proteinOrgans/Tissues associated with 4 1BBR recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >339 publications with 4 1BBR and Necrosis
 Disease Models, Animal Antibodies  >102 publications with 4 1BBR and Disease Models, Animal
 Death Antibodies  >81 publications with 4 1BBR and Death
 Neoplasms, Experimental Antibodies  >71 publications with 4 1BBR and Neoplasms, Experimental
 Inflammation Antibodies  >53 publications with 4 1BBR and Inflammation
 Skin Diseases Antibodies  >32 publications with 4 1BBR and Skin Diseases
 Lung Diseases Antibodies  >30 publications with 4 1BBR and Lung Diseases
 Cardiovascular Diseases Antibodies  >22 publications with 4 1BBR and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >20 publications with 4 1BBR and Nervous System Diseases
 Liver Diseases Antibodies  >20 publications with 4 1BBR and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Adipose Tissue Antibodies  >5 publications with 4 1BBR and Adipose Tissue
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