AAA53133.1
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UniProt Related Accession #
Molecular Weight
27,899 Da
NCBI Official Full Name
4-1BB
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily member 9
NCBI Protein Information
tumor necrosis factor receptor superfamily member 9
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA; CD_antigen: CD137
UniProt Synonym Gene Names
UniProt Entry Name
TNR9_HUMAN
NCBI Summary for 4-1BB /TNFRSF9
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for 4-1BB /TNFRSF9
TNFRSF9: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 1p36
Cellular Component: external side of plasma membrane; extracellular space; integral to plasma membrane
Molecular Function: cytokine binding; receptor activity; tumor necrosis factor receptor activity
Biological Process: apoptosis; immune response; induction of apoptosis via death domain receptors; inflammatory response; multicellular organismal development; negative regulation of cell proliferation; regulation of apoptosis; response to lipopolysaccharide; tumor necrosis factor-mediated signaling pathway
Research Articles on 4-1BB /TNFRSF9
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Products associated with 4-1BB /TNFRSF9 recombinant protein
Pathways associated with 4-1BB /TNFRSF9 recombinant protein
Diseases associated with 4-1BB /TNFRSF9 recombinant protein
Organs/Tissues associated with 4-1BB /TNFRSF9 recombinant protein
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