NP_001552.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
17.7 kDa
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 9
NCBI Official Synonym Full Names
tumor necrosis factor receptor superfamily, member 9
NCBI Protein Information
tumor necrosis factor receptor superfamily member 9; CD137 antigen; T cell antigen ILA; T-cell antigen ILA; 4-1BB ligand receptor; homolog of mouse 4-1BB; receptor protein 4-1BB; T-cell antigen 4-1BB homolog; induced by lymphocyte activation (ILA); interleukin-activated receptor, homolog of mouse Ly63
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 9
UniProt Synonym Protein Names
4-1BB ligand receptor; CDw137; T-cell antigen 4-1BB homolog; T-cell antigen ILA
UniProt Synonym Gene Names
UniProt Entry Name
TNR9_HUMAN
NCBI Summary for TNFRSF9
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq, Jul 2008]
UniProt Comments for TNFRSF9
Function: Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.
Subunit structure: Interacts with TRAF1, TRAF2 and TRAF3. Interacts with LRR-repeat protein 1/LRR-1. Ref.9 Ref.10 Ref.11
Subcellular location: Membrane; Single-pass type I membrane protein.
Tissue specificity: Expressed on the surface of activated T-cells.
Sequence similarities: Contains 4 TNFR-Cys repeats.
Research Articles on TNFRSF9
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Products associated with TNFRSF9 active protein
Pathways associated with TNFRSF9 active protein
Diseases associated with TNFRSF9 active protein
Organs/Tissues associated with TNFRSF9 active protein
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