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ABAT recombinant protein :: 4-aminobutyrate aminotransferase, mitochondrial (ABAT) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS958729
SDS-Page
Unit / Price
0.01 mg (E-Coli)  /  $150 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $980 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,105 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,320 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,355 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,400 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,490 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,010 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,045 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,270 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,645 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

4-aminobutyrate aminotransferase, mitochondrial (ABAT), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human 4-aminobutyrate aminotransferase, mitochondrial (ABAT)

 Product Synonym Names    4-aminobutyrate aminotransferase, mitochondrial; EC=2.6.1.19; (S)-3-amino-2-methylpropionate transaminase; EC=2.6.1.22; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT
 Product Gene Name   

ABAT recombinant protein

[Similar Products]
 Product Synonym Gene Name    ABAT; GABAT [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS958729 COA    COA PDF
 Sequence Positions    29-500.Full-length of the mature protein.
 Sequence    SQAAAKVDVE FDYDGPLMKT EVPGPRSQEL MKQLNIIQNA EAVHFFCNYE ESRGNYLVDV DGNRMLDLYS QISSVPIGYS HPALLKLIQQ PQNASMFVNR PALGILPPEN FVEKLRQSLL SVAPKGMSQL ITMACGSCSN ENALKTIFMW YRSKERGQRG FSQEELETCM INQAPGCPDY SILSFMGAFH GRTMGCLATT HSKAIHKIDI PSFDWPIAPF PRLKYPLEEF VKENQQEEAR CLEEVEDLIV KYRKKKKTVA GIIVEPIQSE GGDNHASDDF FRKLRDIARK HGCAFLVDEV QTGGGCTGKF WAHEHWGLDD PADVMTFSKK MMTGGFFHKE EFRPNAPYRI FNTWLGDPSK NLLLAEVINI IKREDLLNNA AHAGKALLTG LLDLQARYPQ FISRVRGRGT FCSFDTPDDS IRNKLILIAR NKGVVLGGCG DKSIRFRPTL VFRDHHAHLF LNIFSDILAD FK
 OMIM    gene 613163
 3D Structure    ModBase 3D Structure for P80404
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
 Production Note    Special Offer: The E. coli host-expressed protein is manufactured from a stock plasmid containing the protein gene. E. coli host-expressed protein is stocked in different unit sizes ranging from as small as 10 ug to as large as 1 mg. Bulk inventory is also available. The E. coli host-expressed protein has been ordered over and over again by researchers and has stood the test of time as both a robust protein and important target for the research community. It is part of our new program to make our most popular protein targets and corresponding hosts available in expanded unit sizes and with a quick processing time. Select E. coli host-expressed protein for the fastest delivery among all hosts. Please contact us or email to support@mybiosource.com for more details.
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of ABAT recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ABAT recombinant protein

   Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
 Product Categories/Family for ABAT recombinant protein    Neuroscience
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 SDS-Page of ABAT recombinant protein    ABAT recombinant protein SDS-Page image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for ABAT. It may not necessarily be applicable to this product.
 NCBI GI #    38679950
 NCBI GeneID    18
 NCBI Accession #    NP_000654.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000663.4 [Other Products]
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 UniProt Primary Accession #    P80404 [Other Products]
 UniProt Secondary Accession #    Q16260; Q8N5W2; Q96BG2; Q99800; A8K386 [Other Products]
 UniProt Related Accession #    P80404 [Other Products]
 Molecular Weight    56,439 Da
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 NCBI Official Full Name    4-aminobutyrate aminotransferase, mitochondrial
 NCBI Official Synonym Full Names    4-aminobutyrate aminotransferase
 NCBI Official Symbol    ABAT [Similar Products]
 NCBI Official Synonym Symbols   
GABAT; NPD009; GABA-AT
[Similar Products]
 NCBI Protein Information    4-aminobutyrate aminotransferase, mitochondrial; GABA transferase; GABA transaminase; GABA aminotransferase; 4-aminobutyrate transaminase; gamma-amino-N-butyrate transaminase; (S)-3-amino-2-methylpropionate transaminase
 UniProt Protein Name    4-aminobutyrate aminotransferase, mitochondrial
 UniProt Synonym Protein Names   
(S)-3-amino-2-methylpropionate transaminase (EC:2.6.1.22); GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; GABA-T; L-AIBAT
 UniProt Gene Name    ABAT [Similar Products]
 UniProt Synonym Gene Names    GABAT; GABA-AT; GABA transaminase; GABA-T [Similar Products]
 UniProt Entry Name    GABT_HUMAN
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 NCBI Summary for ABAT    4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ABAT    ABAT: Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine. Defects in ABAT are a cause of GABA transaminase deficiency (GABATD). The phenotype of this deficiency includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Protein type: EC 2.6.1.19; Mitochondrial; Transferase; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine; Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - propanoate; EC 2.6.1.22; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 16p13.2

Cellular Component: neuron projection; mitochondrion; mitochondrial matrix; 4-aminobutyrate transaminase complex

Molecular Function: protein homodimerization activity; succinate-semialdehyde dehydrogenase binding; (S)-3-amino-2-methylpropionate transaminase activity; 4-aminobutyrate transaminase activity; pyridoxal phosphate binding

Biological Process: response to nicotine; response to drug; copulation; neurotransmitter catabolic process; neurotransmitter secretion; locomotory behavior; synaptic transmission; response to ethanol; behavioral response to cocaine; response to hypoxia; negative regulation of blood pressure; gamma-aminobutyric acid catabolic process; response to iron ion

Disease: Gaba-transaminase Deficiency
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 Research Articles on ABAT    1. Findings point to a possible role of ABAT gene-regulated GABA catabolism for an altered processing of somatosensory stimuli as a potential vulnerability marker for affective disorders.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ABAT recombinant proteinPathways associated with ABAT recombinant protein
 Reference Product  PubMed Publications
 GAD1 recombinant protein  >1 publications with ABAT and GAD1
 GAD2 recombinant protein  >1 publications with ABAT and GAD2
 ALDH5A1 recombinant protein  >1 publications with ABAT and ALDH5A1
 Products by Pathway  Pathway Diagram
 4-aminobutyrate Degradation I Pathway antibodies  4-aminobutyrate Degradation I Pathway Diagram
 4-aminobutyrate Degradation I Pathway antibodies  4-aminobutyrate Degradation I Pathway Diagram
 Alanine And Aspartate Metabolism Pathway antibodies  Alanine And Aspartate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Alanine, Aspartate And Glutamate Metabolism Pathway antibodies  Alanine, Aspartate And Glutamate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Butanoate Metabolism Pathway antibodies  Butanoate Metabolism Pathway Diagram
 Degradation Of GABA Pathway antibodies  Degradation Of GABA Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
 GABA (gamma-Aminobutyrate) Shunt Pathway antibodies  GABA (gamma-Aminobutyrate) Shunt Pathway Diagram
Diseases associated with ABAT recombinant proteinOrgans/Tissues associated with ABAT recombinant protein
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >5 publications with ABAT and Nervous System Diseases
 Drug Toxicity Antibodies  >4 publications with ABAT and Drug Toxicity
 Genetic Predisposition to Disease Antibodies  >4 publications with ABAT and Genetic Predisposition to Disease
 Brain Diseases Antibodies  >3 publications with ABAT and Brain Diseases
 Cardiovascular Diseases Antibodies  >3 publications with ABAT and Cardiovascular Diseases
 Kidney Diseases Antibodies  >2 publications with ABAT and Kidney Diseases
 Necrosis Antibodies  >2 publications with ABAT and Necrosis
 Autistic Disorder Antibodies  >2 publications with ABAT and Autistic Disorder
 Hypertension Antibodies  >1 publications with ABAT and Hypertension
 Neurotoxicity Syndromes Antibodies  >1 publications with ABAT and Neurotoxicity Syndromes
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with ABAT and Brain
 Bone Antibodies  >6 publications with ABAT and Bone
 Blood Antibodies  >6 publications with ABAT and Blood
 Liver Antibodies  >5 publications with ABAT and Liver
 Muscle Antibodies  >2 publications with ABAT and Muscle
 Kidney Antibodies  >2 publications with ABAT and Kidney
 Heart Antibodies  >1 publications with ABAT and Heart
 Lymph Antibodies  >1 publications with ABAT and Lymph
 Lymph Node Antibodies  >1 publications with ABAT and Lymph Node
 Skin Antibodies  >1 publications with ABAT and Skin
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