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RPS3 recombinant protein :: 40S ribosomal protein S3 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS947991
SDS-PAGE
Unit / Price
0.01 mg (E-Coli)  /  $135 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $255 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $420 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $665 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $785 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $930 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,055 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,170 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,175 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,190 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $1,695 +2 FREE 8GB USB
1 mg (E-Coli)  /  $1,725 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $1,780 +2 FREE 8GB USB
1 mg (Yeast)  /  $1,810 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,260 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

40S ribosomal protein S3 (RPS3), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human 40S ribosomal protein S3

 Product Synonym Names    Homo sapiens (Human)
 Product Gene Name   

RPS3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    2-243aa; Full Length
 Sequence    AVQISKKRKF VADGIFKAEL NEFLTRELAE DGYSGVEVRV TPTRTEIIIL ATRTQNVLGE KGRRIRELTA VVQKRFGFPE GSVELYAEKV ATRGLCAIAQ AESLRYKLLG GLAVRRACYG VLRFIMESGA KGCEVVVSGK LRGQRAKSMK FVDGLMIHSG DPVNYYVDTA VRHVLLRQGV LGIKVKIMLP WDPTGKIGPK KPLPDHVSIV EPKDEILPTT PISEQKGGKP EPPAMPQPVP TA
 OMIM    600454
 3D Structure    ModBase 3D Structure for P23396
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of RPS3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for RPS3 recombinant protein

   Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in cells exposed to hydrogen peroxide (PubMed:17049931). Plays a role in regulating transcription as part of the NF-kappa-B p65-p50 complex where it binds to the RELA/p65 subunit, enhances binding of the complex to DNA and promotes transcription of target genes (PubMed:18045535). Represses its own translation by binding to its cognate mRNA (PubMed:20217897). Binds to and protects TP53/p53 from MDM2-mediated ubiquitination (PubMed:19656744). Involved in spindle formation and chromosome movement during mitosis by regulating microtubule polymerization (PubMed:23131551). Involved in induction of apoptosis through its role in activation of CASP8 (PubMed:14988002). Induces neuronal apoptosis by interacting with the E2F1 transcription factor and acting synergistically with it to up-regulate pro-apoptotic proteins BCL2L11/BIM and HRK/Dp5 (PubMed:20605787). Interacts with TRADD following exposure to UV radiation and induces apoptosis by caspase-dependent JNK activation (PubMed:22510408).
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 SDS-PAGE of RPS3 recombinant protein    RPS3 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for RPS3. It may not necessarily be applicable to this product.
 NCBI GI #    15718687
 NCBI GeneID    6188
 NCBI Accession #    NP_000996.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005.4 [Other Products]
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 UniProt Primary Accession #    P23396 [Other Products]
 UniProt Secondary Accession #    Q498B5; Q8NI95; B2R7N5; J3KN86 [Other Products]
 UniProt Related Accession #    P23396 [Other Products]
 Molecular Weight    42.54kD
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 NCBI Official Full Name    40S ribosomal protein S3 isoform 1
 NCBI Official Synonym Full Names    ribosomal protein S3
 NCBI Official Symbol    RPS3 [Similar Products]
 NCBI Official Synonym Symbols   
S3
[Similar Products]
 NCBI Protein Information    40S ribosomal protein S3
 UniProt Protein Name    40S ribosomal protein S3
 Protein Family    40S ribosomal protein
 UniProt Gene Name    RPS3 [Similar Products]
 UniProt Entry Name    RS3_HUMAN
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 NCBI Summary for RPS3    Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit, where it forms part of the domain where translation is initiated. The protein belongs to the S3P family of ribosomal proteins. Studies of the mouse and rat proteins have demonstrated that the protein has an extraribosomal role as an endonuclease involved in the repair of UV-induced DNA damage. The protein appears to be located in both the cytoplasm and nucleus but not in the nucleolus. Higher levels of expression of this gene in colon adenocarcinomas and adenomatous polyps compared to adjacent normal colonic mucosa have been observed. This gene is co-transcribed with the small nucleolar RNA genes U15A and U15B, which are located in its first and fifth introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for RPS3    RPS3: a component of the 40S ribosomal subunit of eukaryotes. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Identified in a HCV IRES-mediated translation complex, at least composed of EIF3C, IGF2BP1, RPS3 and HCV RNA-replicon. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Overexpressed in colorectal cancer.

Protein type: RNA-binding; EC 4.2.99.18; Apoptosis; Translation; Ribosomal

Chromosomal Location of Human Ortholog: 11q13.3-q13.5

Cellular Component: cytoplasm; cytosol; dendrite; endomembrane system; focal adhesion; membrane; mitochondrial inner membrane; mitochondrial matrix; nucleolus; nucleus; plasma membrane; polysome; ribonucleoprotein complex; ribosome

Molecular Function: damaged DNA binding; DNA binding; DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) lyase activity; endodeoxyribonuclease activity; enzyme binding; Hsp70 protein binding; Hsp90 protein binding; iron-sulfur cluster binding; kinase binding; microtubule binding; mRNA binding; NF-kappaB binding; oxidized purine base lesion DNA N-glycosylase activity; oxidized purine DNA binding; oxidized pyrimidine DNA binding; protein binding; protein kinase A binding; protein kinase binding; RNA binding; structural constituent of ribosome; SUMO binding; transcription factor binding; tubulin binding

Biological Process: activation of NF-kappaB transcription factor; cell division; cellular protein metabolic process; chromosome segregation; DNA damage response, detection of DNA damage; DNA repair; gene expression; mitosis; mRNA catabolic process, nonsense-mediated decay; negative regulation of DNA repair; negative regulation of protein ubiquitination; negative regulation of translation; positive regulation of DNA repair; positive regulation of endodeoxyribonuclease activity; positive regulation of JNK activity; positive regulation of microtubule polymerization; regulation of apoptosis; response to DNA damage stimulus; response to oxidative stress; selenium metabolic process; selenocysteine metabolic process; spindle assembly; SRP-dependent cotranslational protein targeting to membrane; transcription, DNA-dependent; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription
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Product References and Citations for RPS3 recombinant protein

   "Isolation of a cDNA encoding human 40S ribosomal protein s3." Zhang X.T., Tan Y.M., Tan Y.H. Nucleic Acids Res. 18:6689-6689(1990)
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 Research Articles on RPS3    1. Increased RPS3 expression is associated with osteosarcoma invasion.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with RPS3 recombinant proteinPathways associated with RPS3 recombinant protein
 Reference Product  PubMed Publications
 RPS2 recombinant protein  >14 publications with RPS3 and RPS2
 RPS14 recombinant protein  >8 publications with RPS3 and RPS14
 RPS8 recombinant protein  >7 publications with RPS3 and RPS8
 RPS11 recombinant protein  >7 publications with RPS3 and RPS11
 RPS5 recombinant protein  >5 publications with RPS3 and RPS5
 RPS20 recombinant protein  >2 publications with RPS3 and RPS20
 RPS15A recombinant protein  >1 publications with RPS3 and RPS15A
 RPS13 recombinant protein  >1 publications with RPS3 and RPS13
 RPS23 recombinant protein  >1 publications with RPS3 and RPS23
 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Cytoplasmic Ribosomal Proteins Pathway antibodies  Cytoplasmic Ribosomal Proteins Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Eukaryotic Translation Elongation Pathway antibodies  Eukaryotic Translation Elongation Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Eukaryotic Translation Termination Pathway antibodies  Eukaryotic Translation Termination Pathway Diagram
 Formation Of A Pool Of Free 40S Subunits Pathway antibodies  Formation Of A Pool Of Free 40S Subunits Pathway Diagram
 Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway antibodies  Formation Of The Ternary Complex, And Subsequently, The 43S Complex Pathway Diagram
 GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway antibodies  GTP Hydrolysis And Joining Of The 60S Ribosomal Subunit Pathway Diagram
Diseases associated with RPS3 recombinant proteinOrgans/Tissues associated with RPS3 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >7 publications with RPS3 and Inflammation
 Necrosis Antibodies  >6 publications with RPS3 and Necrosis
 Infertility, Male Antibodies  >3 publications with RPS3 and Infertility, Male
 Edema Antibodies  >2 publications with RPS3 and Edema
 Breast Neoplasms Antibodies  >1 publications with RPS3 and Breast Neoplasms
 Embryo Loss Antibodies  >1 publications with RPS3 and Embryo Loss
 Disease Models, Animal Antibodies  >1 publications with RPS3 and Disease Models, Animal
 Carcinoma, Hepatocellular Antibodies  >1 publications with RPS3 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with RPS3 and Liver Neoplasms
 Adenocarcinoma Antibodies  >1 publications with RPS3 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >9 publications with RPS3 and Brain
 Kidney Antibodies  >4 publications with RPS3 and Kidney
 Skin Antibodies  >4 publications with RPS3 and Skin
 Blood Antibodies  >3 publications with RPS3 and Blood
 Bone Antibodies  >3 publications with RPS3 and Bone
 Lung Antibodies  >3 publications with RPS3 and Lung
 Liver Antibodies  >2 publications with RPS3 and Liver
 Eye Antibodies  >2 publications with RPS3 and Eye
 Pancreas Antibodies  >2 publications with RPS3 and Pancreas
 Nerve Antibodies  >2 publications with RPS3 and Nerve
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