NP_112479.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Official Synonym Full Names
tyrosinase-related protein 1
NCBI Official Synonym Symbols
b; isa; TRP1; Tyrp; TRP-1; brown [Similar Products]
NCBI Protein Information
5,6-dihydroxyindole-2-carboxylic acid oxidase; TRP; catalase B; DHICA oxidase; brown locus protein; iris stromal atrophy; tyrosinase related protein
UniProt Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Synonym Protein Names
Brown locus protein; Catalase B; Tyrosinase-related protein 1
UniProt Synonym Gene Names
UniProt Entry Name
TYRP1_MOUSE
UniProt Comments for Tyrp1
TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.
Protein type: Amino Acid Metabolism - tyrosine; EC 1.14.18.-; Membrane protein, integral; Oxidoreductase
Cellular Component: membrane; melanosome membrane; integral to membrane; melanosome; endosome membrane
Molecular Function: 6-hydroxy pseudo-oxynicotine monooxygenase activity; protein binding; protein homodimerization activity; copper ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen; protein heterodimerization activity; metal ion binding; oxidoreductase activity; monooxygenase activity
Biological Process: melanin biosynthetic process; melanin metabolic process; pigmentation; metabolic process; melanosome organization and biogenesis; melanocyte differentiation; melanin biosynthetic process from tyrosine; acetoacetic acid metabolic process
Research Articles on Tyrp1
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Pathways associated with Tyrp1 recombinant protein
Diseases associated with Tyrp1 recombinant protein
Organs/Tissues associated with Tyrp1 recombinant protein
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