NP_000541.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
60,724 Da
NCBI Official Full Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
NCBI Official Synonym Full Names
tyrosinase related protein 1
NCBI Official Synonym Symbols
TRP; CAS2; CATB; GP75; OCA3; TRP1; TYRP; b-PROTEIN [Similar Products]
NCBI Protein Information
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Protein Name
5,6-dihydroxyindole-2-carboxylic acid oxidase
UniProt Synonym Protein Names
Catalase B; Glycoprotein 75; Melanoma antigen gp75; Tyrosinase-related protein 1; TRP; TRP-1; TRP1
UniProt Synonym Gene Names
UniProt Entry Name
TYRP1_HUMAN
NCBI Summary for TYRP1
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. [provided by RefSeq, Mar 2009]
UniProt Comments for TYRP1
TYRP1: Oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Defects in TYRP1 are the cause of albinism oculocutaneous type 3 (OCA3); also known as Rufous oculocutaneous albinism. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Tyrosinase activity is normal and patients have only moderate reduction of pigment. The eyes present red reflex on transillumination of the iris, dilution of color of iris, nystagmus and strabismus. Darker-skinned individuals have bright copper-red coloration of the skin and hair. Belongs to the tyrosinase family.
Protein type: Amino Acid Metabolism - tyrosine; Oxidoreductase; Membrane protein, integral; EC 1.14.18.-
Chromosomal Location of Human Ortholog: 9p23
Cellular Component: endosome membrane; melanosome; melanosome membrane
Molecular Function: protein binding; protein heterodimerization activity; protein homodimerization activity
Biological Process: positive regulation of melanin biosynthetic process
Disease: Albinism, Oculocutaneous, Type Iii; Skin/hair/eye Pigmentation, Variation In, 11
Research Articles on TYRP1
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Products associated with TYRP1 recombinant protein
Pathways associated with TYRP1 recombinant protein
Diseases associated with TYRP1 recombinant protein
Organs/Tissues associated with TYRP1 recombinant protein
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