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PRKAA1 recombinant protein :: 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1476756 PRKAA1 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $985 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,175 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,320 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,420 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,425 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,455 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,490 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,605 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,070 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,130 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,145 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,445 +3 FREE 8GB USB
1 mg (Baculovirus)  /  $2,800 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1), Recombinant Protein

 Also Known As   

Recombinant Human 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

 Product Gene Name   

PRKAA1 recombinant protein

[Similar Products]
 Product Synonym Gene Name    PRKAA1 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-559aa, full length protein
 Sequence    MRRLSSWRKM ATAEKQKHDG RVKIGHYILG DTLGVGTFGK VKVGKHELTG HKVAVKILNR QKIRSLDVVG KIRREIQNLK LFRHPHIIKL YQVISTPSDI FMVMEYVSGG ELFDYICKNG RLDEKESRRL FQQILSGVDY CHRHMVVHRD LKPENVLLDA HMNAKIADFG LSNMMSDGEF LRTSCGSPNY AAPEVISGRL YAGPEVDIWS SGVILYALLC GTLPFDDDHV PTLFKKICDG IFYTPQYLNP SVISLLKHML QVDPMKRATI KDIREHEWFK QDLPKYLFPE DPSYSSTMID DEALKEVCEK FECSEEEVLS CLYNRNHQDP LAVAYHLIID NRRIMNEAKD FYLATSPPDS FLDDHHLTRP HPERVPFLVA ETPRARHTLD ELNPQKSKHQ GVRKAKWHLG IRSQSRPNDI MAEVCRAIKQ LDYEWKVVNP YYLRVRRKNP VTSTYSKMSL QLYQVDSRTY LLDFRSIDDE ITEAKSGTAT PQRSGSVSNY RSCQRSDSDA EAQGKSSEVS LTSSVTSLDS SPVDLTPRPG SHTIEFFEMC ANLIKILAQ
 OMIM    602739
 3D Structure    ModBase 3D Structure for Q13131
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >85% (SDS-PAGE) (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Human
 Storage Buffer    Tris-based buffer, 50% glycerol
 Tag Information    Tag type will be determined during the manufacturing process
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of PRKAA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for PRKAA1 recombinant protein

   This protein belongs to the ser
thr protein kinase family. It is the catalytic subunit of the 5 -prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP
ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
NCBI/Uniprot data below describe general gene information for PRKAA1. It may not necessarily be applicable to this product.
 NCBI GI #    94557301
 NCBI GeneID    5562
 NCBI Accession #    NP_006242.5 [Other Products]
 NCBI GenBank Nucleotide #    NM_006251.5 [Other Products]
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 UniProt Primary Accession #    Q13131 [Other Products]
 UniProt Secondary Accession #    O00286; Q5D0E1; Q86VS1; Q9UNQ4; A8MTQ6; B2R7E1 [Other Products]
 UniProt Related Accession #    Q13131 [Other Products]
 Molecular Weight    65,523 Da
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 NCBI Official Full Name    5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1
 NCBI Official Synonym Full Names    protein kinase AMP-activated catalytic subunit alpha 1
 NCBI Official Symbol    PRKAA1 [Similar Products]
 NCBI Official Synonym Symbols   
AMPK; AMPKa1
[Similar Products]
 NCBI Protein Information    5'-AMP-activated protein kinase catalytic subunit alpha-1
 UniProt Protein Name    5'-AMP-activated protein kinase catalytic subunit alpha-1
 UniProt Synonym Protein Names   
Acetyl-CoA carboxylase kinase (EC:2.7.11.27
 UniProt Gene Name    PRKAA1 [Similar Products]
 UniProt Synonym Gene Names    AMPK1; HMGCR kinase [Similar Products]
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 NCBI Summary for PRKAA1    The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for PRKAA1    Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates 'Ser-36' of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also has tau-protein kinase activity: in response to amyloid beta A4 protein (APP) exposure, activated by CAMKK2, leading to phosphorylation of MAPT/TAU; however the relevance of such data remains unclear in vivo. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1.
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 Research Articles on PRKAA1    1. Our data indicated that miR-451 relays environmental signals by upregulating the activity of AMPK signaling, thereby modulating the activation of mTOR and Rac1/cofilin which, in turn, play key roles in glioma cell proliferation and migration, respectively. Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltratio
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with PRKAA1 recombinant proteinPathways associated with PRKAA1 recombinant protein
 Reference Product  PubMed Publications
 PRKAA2 recombinant protein  >73 publications with PRKAA1 and PRKAA2
 PRKAG1 recombinant protein  >18 publications with PRKAA1 and PRKAG1
 PRKAB1 recombinant protein  >17 publications with PRKAA1 and PRKAB1
 PRKAB2 recombinant protein  >16 publications with PRKAA1 and PRKAB2
 STK11 recombinant protein  >15 publications with PRKAA1 and STK11
 PRKAG3 recombinant protein  >13 publications with PRKAA1 and PRKAG3
 PRKAG2 recombinant protein  >9 publications with PRKAA1 and PRKAG2
 TSC2 recombinant protein  >2 publications with PRKAA1 and TSC2
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Diseases associated with PRKAA1 recombinant proteinOrgans/Tissues associated with PRKAA1 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with PRKAA1 and Neoplasms
 Cardiovascular Diseases Antibodies  >11 publications with PRKAA1 and Cardiovascular Diseases
 Death Antibodies  >10 publications with PRKAA1 and Death
 Heart Diseases Antibodies  >9 publications with PRKAA1 and Heart Diseases
 Fatty Liver Antibodies  >9 publications with PRKAA1 and Fatty Liver
 Inflammation Antibodies  >8 publications with PRKAA1 and Inflammation
 Necrosis Antibodies  >7 publications with PRKAA1 and Necrosis
 Insulin Resistance Antibodies  >6 publications with PRKAA1 and Insulin Resistance
 Liver Diseases Antibodies  >5 publications with PRKAA1 and Liver Diseases
 Nervous System Diseases Antibodies  >4 publications with PRKAA1 and Nervous System Diseases
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >42 publications with PRKAA1 and Muscle
 Liver Antibodies  >20 publications with PRKAA1 and Liver
 Blood Antibodies  >18 publications with PRKAA1 and Blood
 Vascular Antibodies  >13 publications with PRKAA1 and Vascular
 Adipose Tissue Antibodies  >12 publications with PRKAA1 and Adipose Tissue
 Brain Antibodies  >10 publications with PRKAA1 and Brain
 Lung Antibodies  >9 publications with PRKAA1 and Lung
 Pancreas Antibodies  >7 publications with PRKAA1 and Pancreas
 Connective Tissue Antibodies  >6 publications with PRKAA1 and Connective Tissue
 Placenta Antibodies  >5 publications with PRKAA1 and Placenta
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