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Prkag3 recombinant protein :: 5'-AMP-activated protein kinase subunit gamma-3 (Prkag3) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1322214 Prkag3 recombinant protein
Unit / Price
0.05 mg (E-Coli)  /  $910 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $995 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,120 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,220 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $1,340 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,345 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,370 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,420 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,515 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,910 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,035 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,065 +2 FREE 8GB USB
1 mg (Yeast)  /  $2,305 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,675 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5'-AMP-activated protein kinase subunit gamma-3 (Prkag3), Recombinant Protein

 Also Known As   

Recombinant Mouse 5'-AMP-activated protein kinase subunit gamma-3 (Prkag3)

 Product Synonym Names    5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK subunit gamma-3
 Product Gene Name   

Prkag3 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-489aa; full length protein
 Sequence    MEPELEHTLP GTLTWSHSGG PESQEMDFLE QGENSWPSPA VATSSERTCA IRGVKASRWT RQEAVEEAEP PGLGEGAQSR PAAESTRQEA TFPKATPLAQ AVPLAEAETS PTGWDLLLPD CAASAGGSST GDLELTIEFP APEAWDCELE GLGKDRPRPG PSPQAPLLGL SWDDELQKPG AQVYMHFMQE HTCYDAMATS SKLVIFDTTL EIKKAFFAMV ANGVRAAPLW DSKKQSFVGM LTITDFILVL HRYYRSPLVQ IYEIEEHKIE TWREIYLQGC FKPLVSISPN DSLFEAVYAL IKNRIHRLPV LDPVSGTVLY ILTHKRLLKF LHIFGALLPR PSFLCRTIQD LGIGTFRDLA VVLETAPVLT ALDIFVDRRV SALPVVNESG QVVGLYSRFD VIHLAAQQTY NHLDMSVGEA LRQRTLCLEG VLSCQPHESL GEVIDRIARE QVHRLVLVDE TQHLLGVVSL SDILQALVLS PAGIDALSA
 3D Structure    ModBase 3D Structure for Q8BGM7
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Prkag3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Prkag3. It may not necessarily be applicable to this product.
 NCBI GI #    24371223
 NCBI GeneID    241113
 NCBI Accession #    NP_714966.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_153744.3 [Other Products]
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 UniProt Primary Accession #    Q8BGM7 [Other Products]
 UniProt Secondary Accession #    Q0VG42; Q80WK8; Q8CJ41 [Other Products]
 UniProt Related Accession #    Q8BGM7 [Other Products]
 Molecular Weight    51,117 Da
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 NCBI Official Full Name    5'-AMP-activated protein kinase subunit gamma-3
 NCBI Official Synonym Full Names    protein kinase, AMP-activated, gamma 3 non-catatlytic subunit
 NCBI Official Symbol    Prkag3 [Similar Products]
 NCBI Official Synonym Symbols   
Amkg3; Ampkg3; AMPKg3L; AMPKg3S
[Similar Products]
 NCBI Protein Information    5'-AMP-activated protein kinase subunit gamma-3; AMPK gamma3; AMPK subunit gamma-3; AMP-activated protein kinase gamma subunit
 UniProt Protein Name    5'-AMP-activated protein kinase subunit gamma-3
 Protein Family    5'-AMP-activated protein kinase
 UniProt Gene Name    Prkag3 [Similar Products]
 UniProt Synonym Gene Names    AMPK gamma3; AMPK subunit gamma-3 [Similar Products]
 UniProt Entry Name    AAKG3_MOUSE
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 UniProt Comments for Prkag3    AMPKG3: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Skeletal muscle, with weak expression in heart and pancreas. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protein kinase, regulatory subunit

Cellular Component: extracellular space; AMP-activated protein kinase complex

Molecular Function: AMP-activated protein kinase activity; nucleotide binding; protein kinase binding; ATP binding

Biological Process: glycogen biosynthetic process; lipid metabolic process; glucose transport; fatty acid metabolic process; protein amino acid phosphorylation; fatty acid biosynthetic process
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 Research Articles on Prkag3    1. gamma3-AMPK down-regulation is a rapid physiological muscle response observed in mouse after running exercise or fasting, two situations leading to PPARbeta activation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Prkag3 recombinant proteinPathways associated with Prkag3 recombinant protein
 Reference Product  PubMed Publications
 Prkaa2 recombinant protein  >19 publications with Prkag3 and Prkaa2
 Prkag1 recombinant protein  >17 publications with Prkag3 and Prkag1
 Prkaa1 recombinant protein  >14 publications with Prkag3 and Prkaa1
 Prkab2 recombinant protein  >13 publications with Prkag3 and Prkab2
 Prkab1 recombinant protein  >11 publications with Prkag3 and Prkab1
 Prkag2 recombinant protein  >5 publications with Prkag3 and Prkag2
 Tbc1d1 recombinant protein  >1 publications with Prkag3 and Tbc1d1
 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway antibodies  Activation Of PPARGC1A (PGC-1alpha) By Phosphorylation Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Circadian Rhythm Pathway antibodies  Circadian Rhythm Pathway Diagram
 Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway antibodies  Energy Dependent Regulation Of MTOR By LKB1-AMPK Pathway Diagram
 FoxO Signaling Pathway antibodies  FoxO Signaling Pathway Diagram
 Hypertrophic Cardiomyopathy (HCM) Pathway antibodies  Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Diseases associated with Prkag3 recombinant proteinOrgans/Tissues associated with Prkag3 recombinant protein
 Disease Name  Pubmed Publications
 Carcinoma, Squamous Cell Antibodies  >2 publications with Prkag3 and Carcinoma, Squamous Cell
 Weight Gain Antibodies  >2 publications with Prkag3 and Weight Gain
 Genomic Instability Antibodies  >1 publications with Prkag3 and Genomic Instability
 Gonadal Disorders Antibodies  >1 publications with Prkag3 and Gonadal Disorders
 Ovarian Diseases Antibodies  >1 publications with Prkag3 and Ovarian Diseases
 Hypertrophy Antibodies  >1 publications with Prkag3 and Hypertrophy
 Adenocarcinoma Antibodies  >1 publications with Prkag3 and Adenocarcinoma
 Carbohydrate Metabolism, Inborn Errors Antibodies  >1 publications with Prkag3 and Carbohydrate Metabolism, Inborn Errors
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >60 publications with Prkag3 and Muscle
 Brain Antibodies  >1 publications with Prkag3 and Brain
 Embryonic Tissue Antibodies  >1 publications with Prkag3 and Embryonic Tissue
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