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NT5C2 recombinant protein :: 5'-Nucleotidase, Cytosolic II Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS636839 NT5C2 recombinant protein
Unit / Price
0.05 mg  /  $430 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5'-Nucleotidase, Cytosolic II (NT5C2), Recombinant Protein

 Also Known As   

5'-Nucleotidase, Cytosolic II (NT5B) Recombinant, Human

 Product Gene Name   

NT5C2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (104847774..104953063, complement). Location: 10q24.32
 OMIM    600417
 3D Structure    ModBase 3D Structure for P49902
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 Purity/Purification    Highly Purified
Highly purified (95%).
 Form/Format    Supplied as a liquid in 10mM Tris, pH 8.0, 0.1% Triton X-100, 0.002% sodium azide, 10mM DTT.
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 Quality Control    SDS-PAGE
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 12 months.
 Other Notes    Small volumes of NT5C2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for NT5C2 recombinant protein

   Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. The enzyme is exclusively located in the cytoplasmic matrix of cells and may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases.
 Product Categories/Family for NT5C2 recombinant protein    Molecular Biology; MB-Enzymes, Nucleotidase
 Applications Tested/Suitable for NT5C2 recombinant protein   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for NT5C2 recombinant protein    Suitable for use in Suitable for use in ELISA and Western Blot (64.5kD).
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NCBI/Uniprot data below describe general gene information for NT5C2. It may not necessarily be applicable to this product.
 NCBI GI #    12804389
 NCBI GeneID    22978
 NCBI Accession #    AAH01595.1 [Other Products]
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 UniProt Primary Accession #    P49902 [Other Products]
 UniProt Secondary Accession #    Q5JUV5; D3DR91 [Other Products]
 UniProt Related Accession #    P49902 [Other Products]
 Molecular Weight    64,970 Da [Similar Products]
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 NCBI Official Full Name    5'-nucleotidase, cytosolic II
 NCBI Official Synonym Full Names    5'-nucleotidase, cytosolic II
 NCBI Official Symbol    NT5C2 [Similar Products]
 NCBI Official Synonym Symbols   
GMP; NT5B; PNT5; cN-II
[Similar Products]
 NCBI Protein Information    cytosolic purine 5'-nucleotidase; IMP-specific 5'-NT; purine 5' nucleotidase; cytosolic 5'-nucleotidase II; 5'-nucleotidase (purine), cytosolic type B
 UniProt Protein Name    Cytosolic purine 5'-nucleotidase
 UniProt Synonym Protein Names   
Cytosolic 5'-nucleotidase II
 Protein Family    Cytosolic purine 5'-nucleotidase
 UniProt Gene Name    NT5C2 [Similar Products]
 UniProt Synonym Gene Names    NT5B; NT5CP; PNT5 [Similar Products]
 UniProt Entry Name    5NTC_HUMAN
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 NCBI Summary for NT5C2    This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011]
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 UniProt Comments for NT5C2    NT5C2: May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides. Belongs to the 5'(3')-deoxyribonucleotidase family.

Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; EC 3.1.3.5; Hydrolase

Chromosomal Location of Human Ortholog: 10q24.32

Cellular Component: cytosol

Molecular Function: 5'-nucleotidase activity; protein binding; metal ion binding; nucleoside phosphotransferase activity; nucleotide binding

Biological Process: dephosphorylation; nucleobase, nucleoside and nucleotide metabolic process; IMP metabolic process; purine nucleotide catabolic process; drug metabolic process; adenosine metabolic process; phosphorylation; purine base metabolic process
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 Research Articles on NT5C2    1. These results suggest that mutations in NT5C2 are associated with the outgrowth of drug-resistant clones in acute lymphoblastic leukemia
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with NT5C2 recombinant proteinPathways associated with NT5C2 recombinant protein
 Reference Product  PubMed Publications
 DCK recombinant protein  >7 publications with NT5C2 and DCK
 CDA recombinant protein  >3 publications with NT5C2 and CDA
 DCTD recombinant protein  >1 publications with NT5C2 and DCTD
 Products by Pathway  Pathway Diagram
 Abacavir Metabolism Pathway antibodies  Abacavir Metabolism Pathway Diagram
 Abacavir Transport And Metabolism Pathway antibodies  Abacavir Transport And Metabolism Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Nicotinate And Nicotinamide Metabolism Pathway antibodies  Nicotinate And Nicotinamide Metabolism Pathway Diagram
 Purine Catabolism Pathway antibodies  Purine Catabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
Diseases associated with NT5C2 recombinant proteinOrgans/Tissues associated with NT5C2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with NT5C2 and Neoplasms
 Immune System Diseases Antibodies  >3 publications with NT5C2 and Immune System Diseases
 Precursor Cell Lymphoblastic Leukemia-Lymphoma Antibodies  >3 publications with NT5C2 and Precursor Cell Lymphoblastic Leukemia-Lymphoma
 Neoplasms, Experimental Antibodies  >2 publications with NT5C2 and Neoplasms, Experimental
 Recurrence Antibodies  >2 publications with NT5C2 and Recurrence
 Disease Models, Animal Antibodies  >1 publications with NT5C2 and Disease Models, Animal
 Weight Loss Antibodies  >1 publications with NT5C2 and Weight Loss
 Liver Neoplasms Antibodies  >1 publications with NT5C2 and Liver Neoplasms
 Nervous System Diseases Antibodies  >1 publications with NT5C2 and Nervous System Diseases
 Precancerous Conditions Antibodies  >1 publications with NT5C2 and Precancerous Conditions
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >8 publications with NT5C2 and Blood
 Bone Marrow Antibodies  >3 publications with NT5C2 and Bone Marrow
 Bone Antibodies  >3 publications with NT5C2 and Bone
 Lung Antibodies  >2 publications with NT5C2 and Lung
 Brain Antibodies  >2 publications with NT5C2 and Brain
 Adipose Tissue Antibodies  >1 publications with NT5C2 and Adipose Tissue
 Liver Antibodies  >1 publications with NT5C2 and Liver
 Muscle Antibodies  >1 publications with NT5C2 and Muscle
 Vascular Antibodies  >1 publications with NT5C2 and Vascular
 Connective Tissue Antibodies  >1 publications with NT5C2 and Connective Tissue
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