NP_001026671.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
50,830 Da
NCBI Official Full Name
5' exonuclease Apollo
NCBI Official Synonym Full Names
DNA cross-link repair 1B
NCBI Official Synonym Symbols
NCBI Protein Information
5' exonuclease Apollo
UniProt Protein Name
5' exonuclease Apollo
UniProt Synonym Protein Names
DNA cross-link repair 1B protein; SNM1 homolog B
UniProt Synonym Gene Names
UniProt Comments for DCLRE1B
5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways (). May be required for DNA interstrand cross-link repair.
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Products associated with DCLRE1B recombinant protein
Diseases associated with DCLRE1B recombinant protein
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