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Htr1a recombinant protein :: 5-hydroxytryptamine receptor 1A (Htr1a) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS962045 Htr1a recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-hydroxytryptamine receptor 1A (Htr1a), Recombinant Protein

 Also Known As   

Recombinant Rat 5-hydroxytryptamine receptor 1A (Htr1a)

 Product Synonym Names    Recombinant 5-hydroxytryptamine receptor 1A (Htr1a); 5-hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; Serotonin receptor 1A
 Product Gene Name   

Htr1a recombinant protein

[Similar Products]
 Product Synonym Gene Name    Htr1a; 5ht1a [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-422
 Sequence    MDVFSFGQGN NTTASQEPFG TGGNVTSISD VTFSYQVITS LLLGTLIFCA VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV RKVEKKGAGT SLGTSSAPPP KKSLNGQPGS GDWRRCAENR AVGTPCTNGA VRQGDDEATL EVIEVHRVGN SKEHLPLPSE SGSNSYAPAC LERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP FFIVALVLPF CESSCHMPAL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC RR
 Chromosome Location    Chromosome: 2; NC_005101.3 (55362662..55363930). Location: 2q16
 3D Structure    ModBase 3D Structure for P19327
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Htr1a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Htr1a. It may not necessarily be applicable to this product.
 NCBI GI #    6981054
 NCBI GeneID    24473
 NCBI Accession #    NP_036717.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_012585.1 [Other Products]
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 UniProt Primary Accession #    P19327 [Other Products]
 UniProt Related Accession #    P19327 [Other Products]
 Molecular Weight    46,429 Da [Similar Products]
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 NCBI Official Full Name    5-hydroxytryptamine receptor 1A
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
 NCBI Official Symbol    Htr1a [Similar Products]
 NCBI Official Synonym Symbols   
5HT1A; RAT5HT1A
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 1A; 5-HT1A; 5-HT-1A; serotonin receptor 1A
 UniProt Protein Name    5-hydroxytryptamine receptor 1A
 UniProt Synonym Protein Names   
Serotonin receptor 1A
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    Htr1a [Similar Products]
 UniProt Synonym Gene Names    5ht1a; 5-HT-1A; 5-HT1A [Similar Products]
 UniProt Entry Name    5HT1A_RAT
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 NCBI Summary for Htr1a    regulates AMPA receptor channels in the prefrontal cortex; regulation is mediated via inhibition of Ca2+/calmodulin-dependent kinase II [RGD, Feb 2006]
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 UniProt Comments for Htr1a    5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: axon hillock; membrane; cell soma; integral to plasma membrane

Molecular Function: serotonin binding; protein binding; serotonin receptor activity; G-protein alpha-subunit binding; drug binding

Biological Process: vasoconstriction; cell proliferation; G-protein coupled receptor protein signaling pathway; positive regulation of microtubule depolymerization; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of dopamine metabolic process; regulation of serotonin secretion; regulation of hormone secretion; serotonin receptor signaling pathway; serotonin metabolic process; regulation of behavior
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 Research Articles on Htr1a    1. Overall, the present data suggest a preferential action of (+/-)8-OH-DPAT on 5-HT1AR in GABAergic interneurons.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Htr1a recombinant proteinDiseases associated with Htr1a recombinant protein
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >60 publications with Htr1a and Mental Disorders
 Mood Disorders Antibodies  >36 publications with Htr1a and Mood Disorders
 Depressive Disorder Antibodies  >31 publications with Htr1a and Depressive Disorder
 Depressive Disorder, Major Antibodies  >28 publications with Htr1a and Depressive Disorder, Major
 Anxiety Disorders Antibodies  >18 publications with Htr1a and Anxiety Disorders
 Schizophrenia Antibodies  >11 publications with Htr1a and Schizophrenia
 Substance-Related Disorders Antibodies  >10 publications with Htr1a and Substance-Related Disorders
 Nervous System Diseases Antibodies  >10 publications with Htr1a and Nervous System Diseases
 Serotonin Syndrome Antibodies  >10 publications with Htr1a and Serotonin Syndrome
 Personality Disorders Antibodies  >6 publications with Htr1a and Personality Disorders
Organs/Tissues associated with Htr1a recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Mixed Antibodies  >2 publications with Htr1a and Mixed
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