NP_032338.3
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
5-hydroxytryptamine receptor 2C
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 2C
NCBI Official Synonym Symbols
SR1; 5HT1c; Htr1c; 5-HT2C; 5-HT2cR; 5-HTR2C [Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 2C; 5-HT1C; 5-HT-1C; 5-HT-2C; 5-HT2C receptor; serotonin receptor 2C; 5-hydroxytryptamine receptor 1C
UniProt Protein Name
5-hydroxytryptamine receptor 2C
UniProt Synonym Protein Names
5-hydroxytryptamine receptor 1C; 5-HT-1C; 5-HT1C; Serotonin receptor 2C
UniProt Synonym Gene Names
UniProt Entry Name
5HT2C_MOUSE
NCBI Summary for Htr2c
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]
UniProt Comments for Htr2c
5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR
Cellular Component: cell surface; membrane; cell; integral to plasma membrane; integral to membrane; plasma membrane; intracellular; cytosol; external side of plasma membrane
Molecular Function: G-protein coupled receptor activity; signal transducer activity; serotonin binding; serotonin receptor activity; 5-HT2 receptor activity; drug binding
Biological Process: cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); behavioral fear response; G-protein signaling, phospholipase D activating pathway; behavior; behavioral response to nicotine; locomotory behavior; signal transduction; negative regulation of locomotion; feeding behavior; serotonin receptor signaling pathway; positive regulation of acetylcholine secretion; positive regulation of gamma-aminobutyric acid secretion; response to drug; inositol phosphate-mediated signaling; serotonin receptor, phospholipase C activating pathway; regulation of corticotropin-releasing hormone secretion; positive regulation of phosphatidylinositol biosynthetic process; negative regulation of dopamine metabolic process; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; regulation of neurological process; release of sequestered calcium ion into cytosol; regulation of appetite; positive regulation of vasoconstriction; positive regulation of fat cell differentiation; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of sensory perception of pain
Research Articles on Htr2c
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Pathways associated with Htr2c recombinant protein
Diseases associated with Htr2c recombinant protein
Organs/Tissues associated with Htr2c recombinant protein
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