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Htr3a recombinant protein :: 5-hydroxytryptamine receptor 3A (Htr3a) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS955237 Htr3a recombinant protein
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-hydroxytryptamine receptor 3A (Htr3a), Recombinant Protein

 Also Known As   

Recombinant Rat 5-hydroxytryptamine receptor 3A (Htr3a)

 Product Synonym Names    Recombinant 5-hydroxytryptamine receptor 3A (Htr3a); 5-hydroxytryptamine receptor 3A; 5-HT3-A; 5-HT3A; 5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R Serotonin receptor 3A Serotonin-gated ion channel receptor
 Product Gene Name   

Htr3a recombinant protein

[Similar Products]
 Product Synonym Gene Name    Htr3a; 5ht3, Htr3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    24-483
 Sequence    SRRRATQAHS TTQPALLRLS DHLLANYKKG VRPVRDWRKP TLVSIDVIMY AILNVDEKNQ VLTTYIWYRQ FWTDEFLQWT PEDFDNVTKL SIPTDSIWVP DILINEFVDV GKSPSIPYVY VHHQGEVQNY KPLQLVTACS LDIYNFPFDV QNCSLTFTSW LHTIQDINIS LWRTPEEVRS DKSIFINQGE WELLGVFTKF QEFSIETSNS YAEMKFYVVI RRRPLFYAVS LLLPSIFLMV VDIVGFCLPP DSGERVSFKI TLLLGYSVFL IIVSDTLPAT AIGTPLIGVY FVVCMALLVI SLAETIFIVQ LVHKQDLQRP VPDWLRHLVL DRIAWLLCLG EQPMAHRPPA TFQANKTDDC SAMGNHCSHV GSPQDLEKTS RSRDSPLPPP REASLAVRGL LQELSSIRHS LEKRDEMREV ARDWLRVGYV LDRLLFRIYL LAVLAYSITL VTLWSIWHYS
 Chromosome Location    Chromosome: 8; NC_005107.3 (51803897..51816207, complement). Location: 8q23
 3D Structure    ModBase 3D Structure for P35563
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >90%
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Htr3a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for Htr3a. It may not necessarily be applicable to this product.
 NCBI GI #    139947611
 NCBI GeneID    79246
 NCBI Accession #    NP_077370.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_024394.2 [Other Products]
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 UniProt Primary Accession #    P35563 [Other Products]
 UniProt Related Accession #    P35563 [Other Products]
 Molecular Weight    55,428 Da [Similar Products]
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 NCBI Official Full Name    5-hydroxytryptamine receptor 3A
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
 NCBI Official Symbol    Htr3a [Similar Products]
 NCBI Official Synonym Symbols   
5HT3; Htr3; 5-HT3; 5-HT3A
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 3A; 5-HT-3; 5-HT3R; 5-HT3-A; 5-HT3 receptor; serotonin receptor 3A; serotonin-gated ion channel receptor
 UniProt Protein Name    5-hydroxytryptamine receptor 3A
 UniProt Synonym Protein Names   
5-hydroxytryptamine receptor 3; 5-HT-3; 5-HT3R; Serotonin receptor 3A; Serotonin-gated ion channel receptor
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    Htr3a [Similar Products]
 UniProt Synonym Gene Names    5ht3; Htr3; 5-HT3-A; 5-HT3A; 5-HT-3; 5-HT3R [Similar Products]
 UniProt Entry Name    5HT3A_RAT
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 NCBI Summary for Htr3a    receptor for 5-hydroxytryptamine (serotonin); functions as a ligand-gated ion channel [RGD, Feb 2006]
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 UniProt Comments for Htr3a    5-HT(3): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3A sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated; Channel, cation

Cellular Component: postsynaptic membrane; cell soma; integral to plasma membrane; axon; cytoplasm; plasma membrane; cell junction

Molecular Function: serotonin-activated cation-selective channel activity; serotonin binding; voltage-gated potassium channel activity; serotonin receptor activity

Biological Process: synaptic transmission; response to ethanol; response to cocaine; cation transport; serotonin receptor signaling pathway
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 Research Articles on Htr3a    1. Acute myocardial ischemia augments the Bezold-Jarisch reflex induced via activation of TRPV1 and 5-HT(3) receptors located on sensory vagal nerves in the heart.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Htr3a recombinant proteinDiseases associated with Htr3a recombinant protein
 Products by Pathway  Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Ligand-gated Ion Channel Transport Pathway antibodies  Ligand-gated Ion Channel Transport Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Disease Name  Pubmed Publications
 Vomiting Antibodies  >313 publications with Htr3a and Vomiting
 Nervous System Diseases Antibodies  >299 publications with Htr3a and Nervous System Diseases
 Pain Antibodies  >274 publications with Htr3a and Pain
 Nausea Antibodies  >233 publications with Htr3a and Nausea
 Brain Diseases Antibodies  >93 publications with Htr3a and Brain Diseases
 Drug Toxicity Antibodies  >88 publications with Htr3a and Drug Toxicity
 Diarrhea Antibodies  >82 publications with Htr3a and Diarrhea
 Bradycardia Antibodies  >76 publications with Htr3a and Bradycardia
 Substance-Related Disorders Antibodies  >71 publications with Htr3a and Substance-Related Disorders
 Constipation Antibodies  >61 publications with Htr3a and Constipation
Organs/Tissues associated with Htr3a recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >904 publications with Htr3a and Brain
 Dorsal Root Ganglion Antibodies  >34 publications with Htr3a and Dorsal Root Ganglion
 Eye Antibodies  >32 publications with Htr3a and Eye
 Adrenal Gland Antibodies  >11 publications with Htr3a and Adrenal Gland
 Pancreas Antibodies  >9 publications with Htr3a and Pancreas
 Uncharacterized Tissue Antibodies  >2 publications with Htr3a and Uncharacterized Tissue
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