NP_006019.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
5-hydroxytryptamine receptor 3B
NCBI Official Synonym Full Names
5-hydroxytryptamine (serotonin) receptor 3B, ionotropic
NCBI Official Synonym Symbols
NCBI Protein Information
5-hydroxytryptamine receptor 3B; 5-HT3-B; serotonin-gated ion channel subunit; 5-hydroxytryptamine 3 receptor B subunit
UniProt Protein Name
5-hydroxytryptamine receptor 3B
UniProt Synonym Protein Names
Serotonin receptor 3B
UniProt Synonym Gene Names
UniProt Entry Name
5HT3B_HUMAN
NCBI Summary for HTR3B
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit B of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It is not functional as a homomeric complex, but a pentaheteromeric complex with subunit A (HTR3A) displays the full functional features of this receptor. [provided by RefSeq, Aug 2011]
UniProt Comments for HTR3B
5-HT(3B): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. 5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily. HTR3B sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation; Channel, ligand-gated; Transporter, ion channel
Chromosomal Location of Human Ortholog: 11q23.1
Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane
Molecular Function: serotonin-activated cation-selective channel activity; serotonin receptor activity; ion channel activity
Biological Process: synaptic transmission; transport; transmembrane transport; serotonin receptor signaling pathway
Research Articles on HTR3B
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Pathways associated with HTR3B recombinant protein
Diseases associated with HTR3B recombinant protein
Organs/Tissues associated with HTR3B recombinant protein
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