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HTR6 recombinant protein :: 5-hydroxytryptamine receptor 6 (HTR6) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS960239 HTR6 recombinant protein
Unit / Price
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 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

5-hydroxytryptamine receptor 6 (HTR6), Recombinant Protein

 Also Known As   

Recombinant Human 5-hydroxytryptamine receptor 6 (HTR6)

 Product Synonym Names    Recombinant 5-hydroxytryptamine receptor 6 (HTR6); 5-hydroxytryptamine receptor 6; 5-HT-6; 5-HT6; Serotonin receptor 6
 Product Gene Name   

HTR6 recombinant protein

[Similar Products]
 Product Synonym Gene Name    HTR6 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    1-440
 Sequence    MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN
 Chromosome Location    Chromosome: 1; NC_000001.10 (19991780..20006055). Location: 1p36-p35
 OMIM    601109
 3D Structure    ModBase 3D Structure for P50406
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Homo sapiens (Human)
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 Preparation and Storage    Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of HTR6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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NCBI/Uniprot data below describe general gene information for HTR6. It may not necessarily be applicable to this product.
 NCBI GI #    4504545
 NCBI GeneID    3362
 NCBI Accession #    NP_000862.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000871.1 [Other Products]
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 UniProt Primary Accession #    P50406 [Other Products]
 UniProt Secondary Accession #    Q13640; Q5TGZ1 [Other Products]
 UniProt Related Accession #    P50406 [Other Products]
 Molecular Weight    46,954 Da [Similar Products]
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 NCBI Official Full Name    5-hydroxytryptamine receptor 6
 NCBI Official Synonym Full Names    5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled
 NCBI Official Symbol    HTR6 [Similar Products]
 NCBI Official Synonym Symbols   
5-HT6; 5-HT6R
[Similar Products]
 NCBI Protein Information    5-hydroxytryptamine receptor 6; 5-HT-6; serotonin receptor 6
 UniProt Protein Name    5-hydroxytryptamine receptor 6
 UniProt Synonym Protein Names   
Serotonin receptor 6
 Protein Family    5-hydroxytryptamine receptor
 UniProt Gene Name    HTR6 [Similar Products]
 UniProt Synonym Gene Names    5-HT-6; 5-HT6 [Similar Products]
 UniProt Entry Name    5HT6R_HUMAN
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 NCBI Summary for HTR6    This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
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 UniProt Comments for HTR6    5-HT(6): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36-p35

Cellular Component: integral to plasma membrane; dendrite; plasma membrane; cilium

Molecular Function: protein binding; serotonin receptor activity; histamine receptor activity

Biological Process: response to drug; positive regulation of dopamine secretion; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; cerebral cortex cell migration; negative regulation of glutamate secretion; negative regulation of gamma-aminobutyric acid secretion; negative regulation of acetylcholine secretion; learning; response to estradiol stimulus; positive regulation of TOR signaling pathway; serotonin receptor signaling pathway; positive regulation of gamma-aminobutyric acid secretion
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 Research Articles on HTR6    1. There was a statistically significant difference in semantic memory scores among the three genotype groups of T267C in 5-HT6.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with HTR6 recombinant proteinDiseases associated with HTR6 recombinant protein
 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Monoamine GPCRs Pathway antibodies  Monoamine GPCRs Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >13 publications with HTR6 and Mental Disorders
 Schizophrenia Antibodies  >6 publications with HTR6 and Schizophrenia
 Nervous System Diseases Antibodies  >4 publications with HTR6 and Nervous System Diseases
 Mood Disorders Antibodies  >4 publications with HTR6 and Mood Disorders
 Depressive Disorder, Major Antibodies  >3 publications with HTR6 and Depressive Disorder, Major
 Substance-Related Disorders Antibodies  >2 publications with HTR6 and Substance-Related Disorders
 Attention Deficit Disorder with Hyperactivity Antibodies  >2 publications with HTR6 and Attention Deficit Disorder with Hyperactivity
 Poisoning Antibodies  >2 publications with HTR6 and Poisoning
 Dementia Antibodies  >2 publications with HTR6 and Dementia
 Movement Disorders Antibodies  >1 publications with HTR6 and Movement Disorders
Organs/Tissues associated with HTR6 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with HTR6 and Brain
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