Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Recombinant Protein rightarrow PTPS  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • IER3 ELISA Kit
 • TGM2 ELISA Kit
 • Peroxisome proliferators activator alpha (PPAR-alpha) ELISA Kit
 • USP19 Antibody
 • Phospholipase D3 (Pld3) Recombinant Protein
 • Carnitine Acylcarnitine Translocase (CACT) Antibody
 • Anti-Mullerian Hormone (AMH) ELISA Kit
 • CALCRL Antibody
 • ZPI IgG fraction Antibody
 • Goat anti Rabbit IgG (HRP) Secondary Antibody
 • Buprenorphine Protein
 • UBIQUITIN (UBA52) Antibody
 • Bradykinin (BK) ELISA Kit
 • Matrix Metalloproteinase 2 (MMP2) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

PTPS recombinant protein :: 6-Pyruvoyltetrahydropterin Synthase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143670 PTPS recombinant protein
Unit / Price
0.005 mg  /  $140 +1 FREE 8GB USB
0.025 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $2,235 +2 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

6-Pyruvoyltetrahydropterin Synthase (PTPS), Recombinant Protein

 Also Known As   

Recombinant Human 6-Pyruvoyltetrahydropterin Synthase

 Product Synonym Names    PTPS Human; 6-Pyruvoyltetrahydropterin Synthase Human Recombinant; PTP Synthase; 6-Pyruvoyl Tetrahydropterin Synthase; PTPS; PTS; FLJ97081
 Product Gene Name   

PTPS recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Sequence    MGSSHHH HHH SSGLVPRGSH MSTEGGGRRC QAQVSRRISF SASHRLYSKF LSDEENLKLF GKCNNPNGHG HNYKVVVTVH GEIDPATGMV MNLADLKKYM EEAIMQPLDH KNLDMDVPYF ADVVSTTENV AVYIWDNLQK VLPVGVLYKV KVYETDNNIV VYKGE
 OMIM    261640
 3D Structure    ModBase 3D Structure for Q03393
Section Bar
 Host    E Coli
Section Bar
 Purity/Purification    Greater than 95.0% as determined by Analysis by SDS-PAGE.
 Form/Format    6-PyruvoylTetrahydropterin Synthase is formulated in 20mM Tris-HCl buffer pH-8, 1mM DTT and 20% glycerol.
Sterile Filtered colorless solution.
Section Bar
Section Bar
 Preparation and Storage    6-PyruvoylTetrahydropterin Synthase although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
 Other Notes    Small volumes of PTPS recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for PTPS recombinant protein

   Description: 6-PyruvoylTetrahydropterin Synthase Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 165 amino acids (1-145) and having a molecular mass of 18.5kDa. 6-PyruvoylTetrahydropterin Synthase is fused to a 20 amino acid His Tag at N-terminus and purified using conventional chromatography techniques.

Introduction: 6-PyruvoylTetrahydropterin Synthase is part of the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. 6-PyruvoylTetrahydropterin Synthase catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, is a necessary cofactor and regulator of a range of enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in 6-PyruvoylTetrahydropterin Synthase gene result in hyperphenylalaninemia.
 Product Categories/Family for PTPS recombinant protein    ENZYMES; Enzymes; Synthase
NCBI/Uniprot data below describe general gene information for PTPS. It may not necessarily be applicable to this product.
 NCBI GI #    4506331
 NCBI GeneID    5805
 NCBI Accession #    NP_000308.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000317.2 [Other Products]
Section Bar
 UniProt Primary Accession #    Q03393 [Other Products]
 UniProt Secondary Accession #    Q8WVG8; B0YJ87 [Other Products]
 UniProt Related Accession #    Q03393 [Other Products]
 Molecular Weight    16,386 Da
Table BarTOPTable Bar
 NCBI Official Full Name    6-pyruvoyl tetrahydrobiopterin synthase
 NCBI Official Synonym Full Names    6-pyruvoyltetrahydropterin synthase
 NCBI Official Symbol    PTS [Similar Products]
 NCBI Official Synonym Symbols   
PTPS
[Similar Products]
 NCBI Protein Information    6-pyruvoyl tetrahydrobiopterin synthase; PTP synthase
 UniProt Protein Name    6-pyruvoyl tetrahydrobiopterin synthase
 UniProt Gene Name    PTS [Similar Products]
 UniProt Synonym Gene Names    PTP synthase; PTPS [Similar Products]
 UniProt Entry Name    PTPS_HUMAN
Section Bar
 NCBI Summary for PTPS    The enzyme encoded by this gene catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia. [provided by RefSeq, Oct 2008]
Section Bar
 UniProt Comments for PTPS    PTS: Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6- pyruvoyl tetrahydropterin. Defects in PTS are the cause of BH4-deficient hyperphenylalaninemia type A (HPABH4A); also called 6-pyruvoyl-tetrahydropterin synthase deficiency (PTS deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to PTS deficiency. HPABH4A is an autosomal recessive disorder characterized by depletion of the neurotransmitters dopamine and serotonin, and clinically by severe neurological symptoms unresponsive to the classic phenylalanine-low diet. Belongs to the PTPS family.

Protein type: Lyase; Mitochondrial; Cofactor and Vitamin Metabolism - folate biosynthesis; EC 4.2.3.12

Chromosomal Location of Human Ortholog: 11q22.3

Cellular Component: mitochondrion; cytoplasm; cytosol

Molecular Function: identical protein binding; protein homodimerization activity; metal ion binding; 6-pyruvoyltetrahydropterin synthase activity

Biological Process: amino acid metabolic process; tetrahydrobiopterin biosynthetic process; central nervous system development; regulation of nitric-oxide synthase activity; nitric oxide metabolic process

Disease: Hyperphenylalaninemia, Bh4-deficient, A
Table BarTOPTable Bar
 Research Articles on PTPS    1. Severe neurological impairment from BH4 deficiency could be prevented by newborn screening for hyperphenylalaninemia (HPA) and proper metabolic management.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with PTPS recombinant proteinPathways associated with PTPS recombinant protein
 Reference Product  PubMed Publications
 EGFR recombinant protein  >26 publications with PTPS and EGFR
 GCH1 recombinant protein  >9 publications with PTPS and GCH1
 ALPP recombinant protein  >1 publications with PTPS and ALPP
 Products by Pathway  Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Folate Biosynthesis Pathway antibodies  Folate Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Nitric Oxide Pathway antibodies  Metabolism Of Nitric Oxide Pathway Diagram
 Tetrahydrobiopterin (BH4) Synthesis, Recycling, Salvage And Regulation Pathway antibodies  Tetrahydrobiopterin (BH4) Synthesis, Recycling, Salvage And Regulation Pathway Diagram
 ENOS Activation And Regulation Pathway antibodies  ENOS Activation And Regulation Pathway Diagram
 Tetrahydrobiopterin Biosynthesis I Pathway antibodies  Tetrahydrobiopterin Biosynthesis I Pathway Diagram
 Tetrahydrobiopterin Biosynthesis II Pathway antibodies  Tetrahydrobiopterin Biosynthesis II Pathway Diagram
 Tetrahydrobiopterin De Novo Biosynthesis Pathway antibodies  Tetrahydrobiopterin De Novo Biosynthesis Pathway Diagram
Diseases associated with PTPS recombinant proteinOrgans/Tissues associated with PTPS recombinant protein
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >2144 publications with PTPS and Cardiovascular Diseases
 Heart Diseases Antibodies  >1495 publications with PTPS and Heart Diseases
 Death Antibodies  >536 publications with PTPS and Death
 Immune System Diseases Antibodies  >392 publications with PTPS and Immune System Diseases
 Kidney Diseases Antibodies  >320 publications with PTPS and Kidney Diseases
 Neoplasm Metastasis Antibodies  >208 publications with PTPS and Neoplasm Metastasis
 Liver Diseases Antibodies  >175 publications with PTPS and Liver Diseases
 Inflammation Antibodies  >137 publications with PTPS and Inflammation
 Arteriosclerosis Antibodies  >129 publications with PTPS and Arteriosclerosis
 Heart Defects, Congenital Antibodies  >124 publications with PTPS and Heart Defects, Congenital
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1552 publications with PTPS and Blood
 Heart Antibodies  >1260 publications with PTPS and Heart
 Vascular Antibodies  >647 publications with PTPS and Vascular
 Kidney Antibodies  >424 publications with PTPS and Kidney
 Lung Antibodies  >408 publications with PTPS and Lung
 Brain Antibodies  >373 publications with PTPS and Brain
 Liver Antibodies  >292 publications with PTPS and Liver
 Lymph Node Antibodies  >192 publications with PTPS and Lymph Node
 Skin Antibodies  >166 publications with PTPS and Skin
 Ear Antibodies  >126 publications with PTPS and Ear
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions