NP_000987.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
28.5 kDa
NCBI Official Full Name
60S ribosomal protein L35a
NCBI Official Synonym Full Names
ribosomal protein L35a
NCBI Official Synonym Symbols
NCBI Protein Information
60S ribosomal protein L35a
UniProt Protein Name
60S ribosomal protein L35a
UniProt Synonym Protein Names
Cell growth-inhibiting gene 33 protein
UniProt Entry Name
RL35A_HUMAN
NCBI Summary for RPL35A
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L35AE family of ribosomal proteins. It is located in the cytoplasm. The rat protein has been shown to bind to both initiator and elongator tRNAs, and thus, it is located at the P site, or P and A sites, of the ribosome. Although this gene was originally mapped to chromosome 18, it has been established that it is located at 3q29-qter. Alternative splicing results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Oct 2015]
UniProt Comments for RPL35A
RPL35A: Required for the proliferation and viability of hematopoietic cells. Plays a role in 60S ribosomal subunit formation. The protein was found to bind to both initiator and elongator tRNAs and consequently was assigned to the P site or P and A site. Defects in RPL35A are the cause of Diamond-Blackfan anemia type 5 (DBA5). DBA5 is a form of Diamond- Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein L35Ae family.
Protein type: Translation; RNA-binding; Ribosomal
Chromosomal Location of Human Ortholog: 3q29
Cellular Component: cytosol; membrane; mitochondrion
Molecular Function: structural constituent of ribosome; tRNA binding
Biological Process: cellular protein metabolic process; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal large subunit biogenesis and assembly; rRNA processing; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription
Disease: Diamond-blackfan Anemia 5
Product References and Citations for RPL35A recombinant protein
cDNA encoding the human homologue of rat ribosomal protein L35a.Herzog H., Hfferer L., Schneider R., Schweiger M.Nucleic Acids Res. 18:4600-4600(1990)
Identification of a cell growth-inhibiting gene.Kim J.W., Kim H.K.
Research Articles on RPL35A
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Products associated with RPL35A recombinant protein
Diseases associated with RPL35A recombinant protein
Organs/Tissues associated with RPL35A recombinant protein
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