P15126.2
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
34,075 Da
NCBI Official Full Name
60S ribosomal protein L5-B
NCBI Official Synonym Full Names
ribosomal protein L5 L homeolog
NCBI Protein Information
60S ribosomal protein L5-B
UniProt Protein Name
60S ribosomal protein L5-B
UniProt Comments for rpl5-b
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53.
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Pathways associated with rpl5-b recombinant protein
Organs/Tissues associated with rpl5-b recombinant protein
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