NP_001305431.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
66,193 Da
NCBI Official Full Name
72 kDa inositol polyphosphate 5-phosphatase isoform 2
NCBI Official Synonym Full Names
inositol polyphosphate-5-phosphatase E
NCBI Official Synonym Symbols
CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin [Similar Products]
NCBI Protein Information
72 kDa inositol polyphosphate 5-phosphatase
UniProt Protein Name
72 kDa inositol polyphosphate 5-phosphatase
UniProt Synonym Protein Names
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV
NCBI Summary for INPP5E
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
UniProt Comments for INPP5E
Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.
Research Articles on INPP5E
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Products associated with INPP5E recombinant protein
Pathways associated with INPP5E recombinant protein
Diseases associated with INPP5E recombinant protein
Organs/Tissues associated with INPP5E recombinant protein
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