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Mmp2 recombinant protein :: 72 kDa type IV collagenase Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS1092429
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $110 +1 FREE 8GB USB
0.01 mg (E-Coli)  /  $110 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $190 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $190 +1 FREE 8GB USB
0.1 mg (E-Coli)  /  $285 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $285 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $460 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $460 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $750 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $750 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,170 +1 FREE 8GB USB
1 mg (E-Coli)  /  $1,180 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,180 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,420 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,485 +1 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,125 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,140 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,785 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

72 kDa type IV collagenase (Mmp2), Recombinant Protein

 Also Known As   

Recombinant Rat 72 kDa type IV collagenase

 Product Synonym Names    72 kDa gelatinaseGelatinase A; Matrix metalloproteinase-2; MMP-2
 Product Gene Name   

Mmp2 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence Positions    110-662aa; Full Length
 Sequence    YNFFPRKPKW DKNQITYRII GYTPDLDPET VDDAFARALK VWSDVTPLRF SRIHDGEADI MINFGRWEHG DGYPFDGKDG LLAHAFAPGT GVGGDSHFDD DELWTLGEGQ VVRVKYGNAD GEYCKFPFLF NGREYSSCTD TGRSDGFLWC STTYNFEKDG KYGFCPHEAL FTMGGNGDGQ PCKFPFRFQG TSYNSCTTEG RTDGYRWCGT TEDYDRDKKY GFCPETAMST VGGNSEGAPC VFPFTFLGNK YESCTSAGRS DGKVWCATTT NYDDDRKWGF CPDQGYSLFL VAAHEFGHAM GLEHSQDPGA LMAPIYTYTK NFRLSNDDIK GIQELYGPSP DADTDTGTGP TPTLGPVTPE ICKQDIVFDG IAQIRGEIFF FKDRFIWRTV TPRDKPTGPL LVATFWPELP EKIDAVYEAP QEEKAVFFAG NEYWVYSAST LERGYPKPLT SLGLPPDVQQ VDAAFNWSKN KKTYIFSGDK FWRYNEVKKK MDPGFPKLIA DSWNAIPDNL DAVVDLQGGG HSYFFKGAYY LKLENQSLKS VKFGSIKSDW LGC
 3D Structure    ModBase 3D Structure for P33436
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    Greater than 90% as determined by SDS-PAGE. (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Preparation and Storage    Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Mmp2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for Mmp2 recombinant protein

   Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues. PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrin alpha-v/beta3 on the surface of blood vessels.
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 SDS-PAGE of Mmp2 recombinant protein    Mmp2 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Mmp2. It may not necessarily be applicable to this product.
 NCBI GI #    146262019
 NCBI GeneID    81686
 NCBI Accession #    NP_112316.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_031054.2 [Other Products]
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 UniProt Primary Accession #    P33436 [Other Products]
 UniProt Secondary Accession #    P97581; Q6GMM9 [Other Products]
 Molecular Weight    78.1kD
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 NCBI Official Full Name    72 kDa type IV collagenase
 NCBI Official Synonym Full Names    matrix metallopeptidase 2
 NCBI Official Symbol    Mmp2 [Similar Products]
 UniProt Protein Name    72 kDa type IV collagenase
 UniProt Synonym Protein Names   
72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2
 Protein Family    72 kDa type IV collagenase
 UniProt Gene Name    Mmp2 [Similar Products]
 UniProt Synonym Gene Names    MMP-2 [Similar Products]
 UniProt Entry Name    MMP2_RAT
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 NCBI Summary for Mmp2    plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006]
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 UniProt Comments for Mmp2    Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues ().
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Product References and Citations for Mmp2 recombinant protein

   Homology cloning of rat 72 kDa type IV collagenase cytokine and second-messenger inducibility in glomerular mesangial cells.Marti H.P., McNeil L., Davies M., Martin J., Lovett D.H.Biochem. J. 291:441-446(1993) The cloning of the cDNA encoding rat gelatinase A from a rat skin wound cDNA library.Okada A., Basset P.
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 Research Articles on Mmp2    1. Angiotensin II regulates MMP-2, MMP-9, and TIMP-1 expression and affects collagen deposition.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Mmp2 recombinant proteinPathways associated with Mmp2 recombinant protein
 Reference Product  PubMed Publications
 Timp2 recombinant protein  >345 publications with Mmp2 and Timp2
 Timp1 recombinant protein  >317 publications with Mmp2 and Timp1
 Vegfa recombinant protein  >126 publications with Mmp2 and Vegfa
 Timp3 recombinant protein  >84 publications with Mmp2 and Timp3
 Src recombinant protein  >58 publications with Mmp2 and Src
 Nox1 recombinant protein  >2 publications with Mmp2 and Nox1
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Bladder Cancer Pathway antibodies  Bladder Cancer Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
Diseases associated with Mmp2 recombinant proteinOrgans/Tissues associated with Mmp2 recombinant protein
 Disease Name  Pubmed Publications
 Neoplasm Invasiveness Antibodies  >685 publications with Mmp2 and Neoplasm Invasiveness
 Neoplasm Metastasis Antibodies  >539 publications with Mmp2 and Neoplasm Metastasis
 Inflammation Antibodies  >391 publications with Mmp2 and Inflammation
 Fibrosis Antibodies  >306 publications with Mmp2 and Fibrosis
 Disease Progression Antibodies  >260 publications with Mmp2 and Disease Progression
 Heart Diseases Antibodies  >230 publications with Mmp2 and Heart Diseases
 Necrosis Antibodies  >228 publications with Mmp2 and Necrosis
 Breast Neoplasms Antibodies  >211 publications with Mmp2 and Breast Neoplasms
 Bone Diseases Antibodies  >138 publications with Mmp2 and Bone Diseases
 Carcinoma, Hepatocellular Antibodies  >131 publications with Mmp2 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >454 publications with Mmp2 and Muscle
 Lung Antibodies  >400 publications with Mmp2 and Lung
 Artery Antibodies  >315 publications with Mmp2 and Artery
 Heart Antibodies  >282 publications with Mmp2 and Heart
 Brain Antibodies  >259 publications with Mmp2 and Brain
 Connective Tissue Antibodies  >169 publications with Mmp2 and Connective Tissue
 Embryonic Tissue Antibodies  >147 publications with Mmp2 and Embryonic Tissue
 Eye Antibodies  >118 publications with Mmp2 and Eye
 Prostate Antibodies  >106 publications with Mmp2 and Prostate
 Placenta Antibodies  >102 publications with Mmp2 and Placenta
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