NP_112316.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
Molecular Weight
64.1 kDa
NCBI Official Full Name
72 kDa type IV collagenase
NCBI Official Synonym Full Names
matrix metallopeptidase 2
UniProt Protein Name
72 kDa type IV collagenase
UniProt Synonym Protein Names
72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2
UniProt Synonym Gene Names
UniProt Entry Name
MMP2_RAT
NCBI Summary for Mmp2
plays important roles in wound healing, angiogenesis, platelet aggregation, and tumor metastasis; mediates the response of the intrinsic glomerular mesangial cell to inflammatory stimuli [RGD, Feb 2006]
UniProt Comments for Mmp2
Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues ().
Product References and Citations for Mmp2 recombinant protein
Homology cloning of rat 72 kDa type IV collagenase
cytokine and second-messenger inducibility in glomerular mesangial cells.Marti H.P., McNeil L., Davies M., Martin J., Lovett D.H.Biochem. J. 291:441-446(1993)
The cloning of the cDNA encoding rat gelatinase A from a rat skin wound cDNA library.Okada A., Basset P.
Research Articles on Mmp2
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Products associated with Mmp2 recombinant protein
Pathways associated with Mmp2 recombinant protein
Diseases associated with Mmp2 recombinant protein
Organs/Tissues associated with Mmp2 recombinant protein
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