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Hspa5 recombinant protein :: 78 kDa glucose-regulated protein (Hspa5) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS718537
SDS-PAGE
Unit / Price
0.01 mg (Yeast)  /  $135 +1 FREE 8GB USB
0.05 mg (Yeast)  /  $255 +1 FREE 8GB USB
0.1 mg (Yeast)  /  $420 +1 FREE 8GB USB
0.2 mg (Yeast)  /  $665 +1 FREE 8GB USB
0.05 mg (E-Coli)  /  $1,060 +1 FREE 8GB USB
0.5 mg (Yeast)  /  $1,090 +1 FREE 8GB USB
0.05 mg (Baculovirus)  /  $1,235 +1 FREE 8GB USB
0.2 mg (E-Coli)  /  $1,430 +1 FREE 8GB USB
0.05 mg (Mammalian-Cell)  /  $1,485 +1 FREE 8GB USB
0.1 mg (Baculovirus)  /  $1,565 +1 FREE 8GB USB
0.5 mg (E-Coli)  /  $1,580 +1 FREE 8GB USB
1 mg (Yeast)  /  $1,725 +2 FREE 8GB USB
0.5 mg (Baculovirus)  /  $2,235 +2 FREE 8GB USB
0.1 mg (Mammalian-Cell)  /  $2,235 +2 FREE 8GB USB
1 mg (E-Coli)  /  $2,250 +2 FREE 8GB USB
1 mg (Baculovirus)  /  $2,930 +3 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

78 kDa glucose-regulated protein (Hspa5), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Mouse 78 kDa glucose-regulated protein (Hspa5)

 Product Synonym Names    78 kDa glucose-regulated protein; GRP-78; Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP
 Product Gene Name   

Hspa5 recombinant protein

[Similar Products]
 Product Synonym Gene Name    Hspa5; Grp78 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 MBS718537 COA    COA PDF
 Sequence Positions    20-655aa; Full length protein
 Sequence    E EEDKKEDVGT VVGIDLGTTY SCVGVFKNGR VEIIANDQGN RITPSYVAFT PEGERLIGDA AKNQLTSNPE NTVFDAKRLI GRTWNDPSVQ QDIKFLPFKV VEKKTKPYIQ VDIGGGQTKT FAPEEISAMV LTKMKETAEA YLGKKVTHAV VTVPAYFNDA QRQATKDAGT IAGLNVMRII NEPTAAAIAY GLDKREGEKN ILVFDLGGGT FDVSLLTIDN GVFEVVATNG DTHLGGEDFD QRVMEHFIKL YKKKTGKDVR KDNRAVQKLR REVEKAKRAL SSQHQARIEI ESFFEGEDFS ETLTRAKFEE LNMDLFRSTM KPVQKVLEDS DLKKSDIDEI VLVGGSTRIP KIQQLVKEFF NGKEPSRGIN PDEAVAYGAA VQAGVLSGDQ DTGDLVLLDV CPLTLGIETV GGVMTKLIPR NTVVPTKKSQ IFSTASDNQP TVTIKVYEGE RPLTKDNHLL GTFDLTGIPP APRGVPQIEV TFEIDVNGIL RVTAEDKGTG NKNKITITND QNRLTPEEIE RMVNDAEKFA EEDKKLKERI DTRNELESYA YSLKNQIGDK EKLGGKLSSE DKETMEKAVE EKIEWLESHQ DADIEDFKAK KKELEEIVQP IISKLYGSGG PPPTGEEDTS EKDEL
 3D Structure    ModBase 3D Structure for P20029
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 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Mus musculus (Mouse)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Hspa5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Hspa5 recombinant protein

   Probably plays a role in facilitating the assembly of multimeric protein complexes inside the endoplasmic reticulum. Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10, probably to facilitate the release of DNAJC10 from its substrate (By similarity).
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 SDS-PAGE of Hspa5 recombinant protein    Hspa5 recombinant protein SDS-PAGE image
(Note: Representative image, actual molecular weight may vary depending on Tag type and expression host)
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NCBI/Uniprot data below describe general gene information for Hspa5. It may not necessarily be applicable to this product.
 NCBI GI #    254540168
 NCBI GeneID    14828
 NCBI Accession #    NP_001156906.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001163434.1 [Other Products]
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 UniProt Primary Accession #    P20029 [Other Products]
 UniProt Secondary Accession #    O35642; Q3UFF2; Q61630 [Other Products]
 UniProt Related Accession #    P20029 [Other Products]
 Molecular Weight    74kD
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 NCBI Official Full Name    78 kDa glucose-regulated protein
 NCBI Official Synonym Full Names    heat shock protein 5
 NCBI Official Symbol    Hspa5 [Similar Products]
 NCBI Official Synonym Symbols   
Bip; Sez7; mBiP; Grp78; SEZ-7; Hsce70; baffled; AL022860; AU019543; D2Wsu17e; D2Wsu141e
[Similar Products]
 NCBI Protein Information    78 kDa glucose-regulated protein; GRP-78; XAP-1 antigen; heat shock 70 kDa protein 5; glucose regulated protein, 78 kDa; immunoglobulin heavy chain-binding protein; heat shock 70kD protein 5 (glucose-regulated protein, 78kD)
 UniProt Protein Name    78 kDa glucose-regulated protein
 UniProt Synonym Protein Names   
Heat shock 70 kDa protein 5; Immunoglobulin heavy chain-binding protein; BiP
 UniProt Gene Name    Hspa5 [Similar Products]
 UniProt Synonym Gene Names    Grp78; GRP-78; BiP [Similar Products]
 UniProt Entry Name    GRP78_MOUSE
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 UniProt Comments for Hspa5    GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Heat shock protein; Chaperone

Cellular Component: signalosome; endoplasmic reticulum membrane; smooth endoplasmic reticulum; cell surface; focal adhesion; mitochondrion; endoplasmic reticulum; endoplasmic reticulum lumen; ER-Golgi intermediate compartment; membrane; cytoplasm; plasma membrane; integral to endoplasmic reticulum membrane; midbody; nucleus; myelin sheath

Molecular Function: protein domain specific binding; protein binding; enzyme binding; ubiquitin protein ligase binding; unfolded protein binding; nucleotide binding; ribosome binding; misfolded protein binding; glycoprotein binding; ATP binding

Biological Process: cellular response to glucose starvation; positive regulation of embryonic development; unfolded protein response, activation of signaling protein activity; cerebellum structural organization; proteolysis involved in cellular protein catabolic process; positive regulation of protein ubiquitination; cerebellar Purkinje cell layer development; negative regulation of transforming growth factor beta receptor signaling pathway; ER overload response; negative regulation of apoptosis; positive regulation of cell migration
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 Research Articles on Hspa5    1. Reg2 induces glucose-regulated peptide 78 (GRP78) expression via the Akt-mTORC1 axis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with Hspa5 recombinant proteinDiseases associated with Hspa5 recombinant protein
 Products by Pathway  Pathway Diagram
 ATF6-alpha Activates Chaperone Genes Pathway antibodies  ATF6-alpha Activates Chaperone Genes Pathway Diagram
 ATF6-alpha Activates Chaperones Pathway antibodies  ATF6-alpha Activates Chaperones Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Prion Diseases Pathway antibodies  Prion Diseases Pathway Diagram
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >60 publications with Hspa5 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >57 publications with Hspa5 and Disease Models, Animal
 Nervous System Diseases Antibodies  >56 publications with Hspa5 and Nervous System Diseases
 Inflammation Antibodies  >33 publications with Hspa5 and Inflammation
 Heart Diseases Antibodies  >21 publications with Hspa5 and Heart Diseases
 Liver Diseases Antibodies  >21 publications with Hspa5 and Liver Diseases
 Necrosis Antibodies  >19 publications with Hspa5 and Necrosis
 Kidney Diseases Antibodies  >13 publications with Hspa5 and Kidney Diseases
 Fibrosis Antibodies  >10 publications with Hspa5 and Fibrosis
 Fatty Liver Antibodies  >10 publications with Hspa5 and Fatty Liver
Organs/Tissues associated with Hspa5 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >76 publications with Hspa5 and Brain
 Muscle Antibodies  >49 publications with Hspa5 and Muscle
 Blood Antibodies  >45 publications with Hspa5 and Blood
 Liver Antibodies  >38 publications with Hspa5 and Liver
 Heart Antibodies  >38 publications with Hspa5 and Heart
 Kidney Antibodies  >30 publications with Hspa5 and Kidney
 Artery Antibodies  >18 publications with Hspa5 and Artery
 Pancreas Antibodies  >16 publications with Hspa5 and Pancreas
 Lung Antibodies  >14 publications with Hspa5 and Lung
 Testis Antibodies  >11 publications with Hspa5 and Testis
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