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Pla2g6 recombinant protein :: 85 kDa calcium-independent phospholipase A2 (Pla2g6) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS968273 Pla2g6 recombinant protein
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 Product Name   

85 kDa calcium-independent phospholipase A2 (Pla2g6), Recombinant Protein

 Also Known As   

Recombinant Rat 85 kDa calcium-independent phospholipase A2 (Pla2g6)

 Product Synonym Names    85 kDa calcium-independent phospholipase A2; CaI-PLA2; iPLA2; EC=3.1.1.4; Group VI phospholipase A2; GVI PLA2
 Product Gene Name   

Pla2g6 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P97570
 Host    E Coli or Yeast or Baculovirus or Mammalian Cell
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 Purity/Purification    >=90% (lot specific)
 Form/Format    Liquid containing glycerol
 Tag Information    This protein contains an N-terminal tag and may also contain a C-terminal Myc-tag. N-terminal host tags may vary (His, His-SUMO, His-B2M, GST). Tag types are determined by various factors including tag-protein stability and, therefore, are subject to change; please inquire for tag information.
 Sterility    Sterile filter available upon request.
 Endotoxin    Low endotoxin available upon request.
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 Species    Rattus norvegicus (Rat)
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 Preparation and Storage    Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of Pla2g6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for Pla2g6 recombinant protein

   This protein is an A2 phospholipase, a class of enzyme that catalyzes the release of fatty acids from phospholipids. The encoded protein may play a role in phospholipid remodelling, arachidonic acid release, leukotriene and prostaglandin synthesis, fas-mediated apoptosis, and transmembrane ion flux in glucose-stimulated B-cells. Several transcript variants encoding multiple isoforms have been described, but the full-length nature of only two of them have been determined to date.
NCBI/Uniprot data below describe general gene information for Pla2g6. It may not necessarily be applicable to this product.
 NCBI GI #    53850648
 NCBI GeneID    360426
 NCBI Accession #    NP_001005560.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005560.1 [Other Products]
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 UniProt Primary Accession #    P97570 [Other Products]
 UniProt Secondary Accession #    Q66HD1; G3V7M8 [Other Products]
 UniProt Related Accession #    P97570 [Other Products]
 Molecular Weight    83,562 Da
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 NCBI Official Full Name    85/88 kDa calcium-independent phospholipase A2 isoform 1
 NCBI Official Synonym Full Names    phospholipase A2, group VI (cytosolic, calcium-independent)
 NCBI Official Symbol    Pla2g6 [Similar Products]
 NCBI Official Synonym Symbols   
iPla2; PNPLA9
[Similar Products]
 NCBI Protein Information    85/88 kDa calcium-independent phospholipase A2; GVI PLA2; caI-PLA2; iPLA2-beta; group VI phospholipase A2; 85 kDa calcium-independent phospholipase A2; patatin-like phospholipase domain-containing protein 9; intracellular membrane-associated calcium-independent phospholipase A2 beta
 UniProt Protein Name    85/88 kDa calcium-independent phospholipase A2
 UniProt Synonym Protein Names   
Group VI phospholipase A2; GVI PLA2; Intracellular membrane-associated calcium-independent phospholipase A2 beta; iPLA2-beta; Patatin-like phospholipase domain-containing protein 9; PNPLA9
 Protein Family    85/88 kDa calcium-independent phospholipase
 UniProt Gene Name    Pla2g6 [Similar Products]
 UniProt Synonym Gene Names    Pnpla9; CaI-PLA2; GVI PLA2; iPLA2-beta; PNPLA9 [Similar Products]
 UniProt Entry Name    PLPL9_RAT
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 NCBI Summary for Pla2g6    has Ca2+ independent phospholipase A2 activity; may play a role in regulating transmembrane ionic fluxes in pancreatic beta cells [RGD, Feb 2006]
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 UniProt Comments for Pla2g6    PLA2G6: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F- actin polymerization at the pseudopods. Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2B (NBIA2B). A neurodegenerative disorder associated with iron accumulation in the brain, primarily in the basal ganglia. It is characterized by progressive extrapyramidal dysfunction leading to rigidity, dystonia, dysarthria and sensorimotor impairment. Defects in PLA2G6 are the cause of neurodegeneration with brain iron accumulation type 2A (NBIA2A); also known as Seitelberger disease. NBIA2A is a neurodegenerative disease characterized by pathologic axonal swelling and spheroid bodies in the central nervous system. Onset is within the first 2 years of life with death by age 10 years. Defects in PLA2G6 are the cause of Parkinson disease type 14 (PARK14). An adult-onset progressive neurodegenerative disorder characterized by parkinsonism, dystonia, severe cognitive decline, cerebral and cerebellar atrophy and absent iron in the basal ganglia on magnetic resonance imaging. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Lipid Metabolism - alpha-linolenic acid; Phospholipase; Lipid Metabolism - linoleic acid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - ether lipid; Lipid Metabolism - arachidonic acid; EC 3.1.1.4

Cellular Component: mitochondrion; cytoplasm; mitochondrial inner membrane; microtubule organizing center; cytosol

Molecular Function: calmodulin binding; ATP-dependent protein binding; calcium-independent phospholipase A2 activity; protein kinase binding

Biological Process: urinary bladder smooth muscle contraction; cardiolipin biosynthetic process; elevation of cytosolic calcium ion concentration; maternal process involved in pregnancy; negative regulation of synaptic transmission, glutamatergic; positive regulation of protein amino acid phosphorylation; chemotaxis; positive regulation of vasodilation; lipid catabolic process; memory; positive regulation of exocytosis
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 Research Articles on Pla2g6    1. acts as an inhibitory modulator of NKCC2 activity in thick ascending limb
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with Pla2g6 recombinant proteinPathways associated with Pla2g6 recombinant protein
 Reference Product  PubMed Publications
 Pla2g4a recombinant protein  >104 publications with Pla2g6 and Pla2g4a
 Ptgs2 recombinant protein  >13 publications with Pla2g6 and Ptgs2
 Ptgs1 recombinant protein  >11 publications with Pla2g6 and Ptgs1
 Alox5 recombinant protein  >2 publications with Pla2g6 and Alox5
 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of CL Pathway antibodies  Acyl Chain Remodeling Of CL Pathway Diagram
 Acyl Chain Remodelling Of PC Pathway antibodies  Acyl Chain Remodelling Of PC Pathway Diagram
 Acyl Chain Remodelling Of PE Pathway antibodies  Acyl Chain Remodelling Of PE Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Eicosanoid Synthesis Pathway antibodies  Eicosanoid Synthesis Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Ether Lipid Metabolism Pathway antibodies  Ether Lipid Metabolism Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
 Fc Gamma R-mediated Phagocytosis Pathway antibodies  Fc Gamma R-mediated Phagocytosis Pathway Diagram
Diseases associated with Pla2g6 recombinant proteinOrgans/Tissues associated with Pla2g6 recombinant protein
 Disease Name  Pubmed Publications
 NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A Antibodies  >41 publications with Pla2g6 and NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 2A
 Inflammation Antibodies  >28 publications with Pla2g6 and Inflammation
 Atrophy Antibodies  >25 publications with Pla2g6 and Atrophy
 Cardiovascular Diseases Antibodies  >18 publications with Pla2g6 and Cardiovascular Diseases
 Ischemia Antibodies  >11 publications with Pla2g6 and Ischemia
 Atherosclerosis Antibodies  >10 publications with Pla2g6 and Atherosclerosis
 Fatty Liver Antibodies  >7 publications with Pla2g6 and Fatty Liver
 Necrosis Antibodies  >6 publications with Pla2g6 and Necrosis
 Neoplasms, Experimental Antibodies  >6 publications with Pla2g6 and Neoplasms, Experimental
 Nerve Degeneration Antibodies  >6 publications with Pla2g6 and Nerve Degeneration
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >72 publications with Pla2g6 and Brain
 Blood Antibodies  >38 publications with Pla2g6 and Blood
 Pancreas Antibodies  >19 publications with Pla2g6 and Pancreas
 Kidney Antibodies  >13 publications with Pla2g6 and Kidney
 Lung Antibodies  >9 publications with Pla2g6 and Lung
 Nerve Antibodies  >9 publications with Pla2g6 and Nerve
 Eye Antibodies  >9 publications with Pla2g6 and Eye
 Skin Antibodies  >7 publications with Pla2g6 and Skin
 Liver Antibodies  >6 publications with Pla2g6 and Liver
 Ovary Antibodies  >5 publications with Pla2g6 and Ovary
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