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ADAM10 recombinant protein :: A Disintegrin And Metalloprotease 10 (ADAM10) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009286 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $150 +1 FREE 8GB USB
0.05 mg  /  $285 +1 FREE 8GB USB
0.1 mg  /  $445 +1 FREE 8GB USB
0.2 mg  /  $550 +1 FREE 8GB USB
0.5 mg  /  $1,060 +1 FREE 8GB USB
1 mg  /  $1,580 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 10 (ADAM10), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloprotease 10 (ADAM10)

 Product Gene Name   

ADAM10 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloprotease 10 (ADAM10) (MBS2004491)
Antigen: A Disintegrin And Metalloprotease 10 (ADAM10) (MBS2009286)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
 Chromosome Location    Chromosome: 8; NC_005107.3 (75842118..75974564, complement). Location: 8q24
 3D Structure    ModBase 3D Structure for Q10743
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Rattus norvegicus (Rat)
 Expression System    Prokaryotic expression
 Residues    Thr218~Asp445 (Accession # Q10743) with N-terminal His-Tag
 Subcellular Location    Membrane; Single-pass type I membrane protein
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Predicted Isoelectric Point    6.4
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ADAM10 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ADAM10 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for ADAM10 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of ADAM10 recombinant protein    ADAM10 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ADAM10. It may not necessarily be applicable to this product.
 NCBI GI #    37096570
 NCBI GeneID    29650
 NCBI Accession #    Q10743.1 [Other Products]
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 UniProt Primary Accession #    Q10743 [Other Products]
 UniProt Related Accession #    Q10743 [Other Products]
 Molecular Weight    26.5kDa
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 NCBI Official Full Name    Disintegrin and metalloproteinase domain-containing protein 10
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 10
 NCBI Official Symbol    Adam10 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 10; ADAM 10; kuzbanian protein homolog; mammalian disintegrin-metalloprotease; a disintegrin and metalloprotease domain 10; a disintegrin and metallopeptidase domain 10
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 10
 UniProt Synonym Protein Names   
Kuzbanian protein homolog; Mammalian disintegrin-metalloprotease
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    Adam10 [Similar Products]
 UniProt Synonym Gene Names    Madm; ADAM 10 [Similar Products]
 UniProt Entry Name    ADA10_RAT
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 NCBI Summary for ADAM10    may act as a disintegrin-metalloprotease related to the reprolysin family [RGD, Feb 2006]
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 UniProt Comments for ADAM10    ADAM10: Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP). Contributes to the normal cleavage of the cellular prion protein. Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity. Controls also the proteolytic processing of Notch. Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form. Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B. May regulate the EFNA5-EPHA3 signaling (By similarity)

Protein type: Motility/polarity/chemotaxis; Protease; Vesicle; EC; Cell surface; Membrane protein, integral; Cell adhesion

Cellular Component: Golgi apparatus; focal adhesion; cell surface; intracellular membrane-bound organelle; membrane; postsynaptic density; cytoplasm; integral to membrane; Golgi-associated vesicle; trans-Golgi network; nucleus

Molecular Function: protein homodimerization activity; zinc ion binding; metallopeptidase activity; metal ion binding; metalloendopeptidase activity; endopeptidase activity; protein kinase binding; SH3 domain binding

Biological Process: PMA-inducible membrane protein ectodomain proteolysis; Notch signaling pathway; regulation of osteoclast differentiation; monocyte activation; in utero embryonic development; membrane protein ectodomain proteolysis; positive regulation of cell proliferation; constitutive protein ectodomain proteolysis; negative regulation of cell adhesion; proteolysis; positive regulation of cell growth; protein amino acid phosphorylation; positive regulation of cell migration
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 Research Articles on ADAM10    1. Time- and injury-dependent expression of MT5-MMP, ADAM-10, and N-cadherin are confirmed during reactive synaptogenesis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAM10 recombinant proteinPathways associated with ADAM10 recombinant protein
 Reference Product  PubMed Publications
 Bace1 recombinant protein  >91 publications with ADAM10 and Bace1
 Egfr recombinant protein  >30 publications with ADAM10 and Egfr
 Notch1 recombinant protein  >14 publications with ADAM10 and Notch1
 Pax2 recombinant protein  >3 publications with ADAM10 and Pax2
 Notch3 recombinant protein  >2 publications with ADAM10 and Notch3
 Notch2 recombinant protein  >2 publications with ADAM10 and Notch2
 Dll1 recombinant protein  >2 publications with ADAM10 and Dll1
 Dlg1 recombinant protein  >2 publications with ADAM10 and Dlg1
 Products by Pathway  Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
Organs/Tissues associated with ADAM10 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >136 publications with ADAM10 and Brain
 Lung Antibodies  >18 publications with ADAM10 and Lung
 Eye Antibodies  >13 publications with ADAM10 and Eye
 Colon Antibodies  >10 publications with ADAM10 and Colon
 Spleen Antibodies  >5 publications with ADAM10 and Spleen
 Ovary Antibodies  >5 publications with ADAM10 and Ovary
 Inner Ear Antibodies  >2 publications with ADAM10 and Inner Ear
 Pineal Gland Antibodies  >1 publications with ADAM10 and Pineal Gland
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