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ADAM17 recombinant protein :: A Disintegrin And Metalloprotease 17 (ADAM17) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011531 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
SDS-PAGE
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloprotease 17 (ADAM17), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloprotease 17 (ADAM17)

 Product Gene Name   

ADAM17 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-KLLVVA D HRFYRYMGRG EESTTTNYLI ELIDRVDDIY RNTSWDNAGF KGYGIQIEQI RILKSPQEVK PGEKHYNMAK SYPNEEKDAW DVKMLLEQFS FDIAEEASKV CLAHLFTYQD FDMGTLGLAY VGSPRANSHG GVCPKAYYSP VGKKNIYLNS GLTSTKNYGK TILTKEADLV TTHELGHNFG AEHDPDGLAE CAPNEDQGGK YVMYPIAVSG DHENNKMFSN CSKQSIYKTI ESKAQECFQE R
 Chromosome Location    Chromosome: 2; NC_000002.11 (9629392..9695917, complement). Location: 2p25
 OMIM    603639
 3D Structure    ModBase 3D Structure for P78536
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Lys226~Arg473 (Accession # P78536) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of ADAM17 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ADAM17 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for ADAM17 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of ADAM17 recombinant protein    ADAM17 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ADAM17. It may not necessarily be applicable to this product.
 NCBI GI #    73747889
 NCBI GeneID    6868
 NCBI Accession #    NP_003174.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_003183.4 [Other Products]
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 UniProt Primary Accession #    P78536 [Other Products]
 UniProt Secondary Accession #    O60226 [Other Products]
 UniProt Related Accession #    P78536 [Other Products]
 Molecular Weight    29.5kDa
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 17 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 17
 NCBI Official Symbol    ADAM17 [Similar Products]
 NCBI Official Synonym Symbols   
CSVP; TACE; NISBD; ADAM18; CD156B
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 17; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; ADAM metallopeptidase domain 18; tumor necrosis factor, alpha, converting enzyme
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 17
 UniProt Synonym Protein Names   
Snake venom-like protease; TNF-alpha convertase; TNF-alpha-converting enzyme
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM17 [Similar Products]
 UniProt Synonym Gene Names    CSVP; TACE; ADAM 17 [Similar Products]
 UniProt Entry Name    ADA17_HUMAN
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 NCBI Summary for ADAM17    This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAM17    TACE: a type I membrane protein with disintegrin and metalloprotease activity. An ubiquitously expressed ectoenzyme of peptidase family M12B. Must be membrane anchored to cleave the different substrates. The cytoplasmic domain is not required for the this activity. Possesses a narrow endopeptidase specificity. Cleaves Pro-Leu-Ala-Gln-Ala-|-Val-Arg-Ser-Ser-Ser in the membrane-bound, 26-kDa form of tumor necrosis factor alpha (TNF-alpha) to its mature soluble form. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, and the amyloid precursor protein. Also involved in the activation of Notch pathway. Binds 1 zinc ion per subunit. Two splice variant isoforms have been described.

Protein type: EC 3.4.24.86; Motility/polarity/chemotaxis; Protease; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p25

Cellular Component: focal adhesion; cell surface; membrane; integral to plasma membrane; cytoplasm; apical plasma membrane; plasma membrane; intercellular junction; lipid raft; actin cytoskeleton

Molecular Function: integrin binding; protein binding; interleukin-6 receptor binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; Notch binding; SH3 domain binding; PDZ domain binding

Biological Process: extracellular matrix organization and biogenesis; nerve growth factor receptor signaling pathway; neutrophil mediated immunity; T cell differentiation in the thymus; cell motility involved in cell locomotion; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; proteolysis; G1/S-specific positive regulation of cyclin-dependent protein kinase activity; extracellular matrix disassembly; positive regulation of epidermal growth factor receptor activity; positive regulation of cell proliferation; germinal center formation; negative regulation of interleukin-8 production; cell adhesion; response to drug; spleen development; epidermal growth factor receptor signaling pathway; Notch signaling pathway; response to high density lipoprotein stimulus; membrane protein intracellular domain proteolysis; membrane protein ectodomain proteolysis; positive regulation of transforming growth factor beta receptor signaling pathway; Notch receptor processing; positive regulation of cell motility; positive regulation of cell growth; positive regulation of chemokine production; regulation of mast cell apoptosis; collagen catabolic process; PMA-inducible membrane protein ectodomain proteolysis; B cell differentiation; response to hypoxia; cell adhesion mediated by integrin; positive regulation of protein amino acid phosphorylation; negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of cell migration; wound healing, spreading of epidermal cells

Disease: Inflammatory Skin And Bowel Disease, Neonatal, 1
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 Research Articles on ADAM17    1. Dengue virus induces CD137 signaling to enhance apoptosis by increasing TNF-alpha production via activation of p38 MAPK.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAM17 recombinant proteinPathways associated with ADAM17 recombinant protein
 Reference Product  PubMed Publications
 EGFR recombinant protein  >115 publications with ADAM17 and EGFR
 ADAM12 recombinant protein  >25 publications with ADAM17 and ADAM12
 TIMP3 recombinant protein  >19 publications with ADAM17 and TIMP3
 NOTCH1 recombinant protein  >12 publications with ADAM17 and NOTCH1
 ERBB2 recombinant protein  >5 publications with ADAM17 and ERBB2
 HBEGF recombinant protein  >1 publications with ADAM17 and HBEGF
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Diseases associated with ADAM17 recombinant proteinOrgans/Tissues associated with ADAM17 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >437 publications with ADAM17 and Necrosis
 Neoplasms Antibodies  >135 publications with ADAM17 and Neoplasms
 Inflammation Antibodies  >101 publications with ADAM17 and Inflammation
 Nervous System Diseases Antibodies  >50 publications with ADAM17 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >43 publications with ADAM17 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >26 publications with ADAM17 and Disease Models, Animal
 Breast Neoplasms Antibodies  >22 publications with ADAM17 and Breast Neoplasms
 Liver Diseases Antibodies  >20 publications with ADAM17 and Liver Diseases
 Atherosclerosis Antibodies  >17 publications with ADAM17 and Atherosclerosis
 Lung Diseases Antibodies  >16 publications with ADAM17 and Lung Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >72 publications with ADAM17 and Brain
 Kidney Antibodies  >36 publications with ADAM17 and Kidney
 Muscle Antibodies  >35 publications with ADAM17 and Muscle
 Lung Antibodies  >35 publications with ADAM17 and Lung
 Liver Antibodies  >34 publications with ADAM17 and Liver
 Embryonic Tissue Antibodies  >29 publications with ADAM17 and Embryonic Tissue
 Ovary Antibodies  >15 publications with ADAM17 and Ovary
 Prostate Antibodies  >11 publications with ADAM17 and Prostate
 Eye Antibodies  >10 publications with ADAM17 and Eye
 Bone Marrow Antibodies  >7 publications with ADAM17 and Bone Marrow
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