AAH92465.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,637 Da
NCBI Official Full Name
ADAM22 protein
NCBI Official Synonym Full Names
ADAM metallopeptidase domain 22
NCBI Protein Information
disintegrin and metalloproteinase domain-containing protein 22
UniProt Protein Name
Disintegrin and metalloproteinase domain-containing protein 22
UniProt Synonym Protein Names
Metalloproteinase-disintegrin ADAM22-3; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 2
UniProt Synonym Gene Names
UniProt Entry Name
ADA22_HUMAN
NCBI Summary for ADAM22
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
UniProt Comments for ADAM22
ADAM22: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Involved in regulation of cell adhesion and spreading and in inhibition of cell proliferation. Neuronal receptor for LGI1. 5 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7q21
Cellular Component: axon; integral to membrane; plasma membrane
Molecular Function: integrin binding; metalloendopeptidase activity; protein binding; zinc ion binding
Biological Process: adult locomotory behavior; cell adhesion; central nervous system development; myelination in the peripheral nervous system; negative regulation of cell adhesion; proteolysis
Research Articles on ADAM22
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Products associated with ADAM22 recombinant protein
Pathways associated with ADAM22 recombinant protein
Diseases associated with ADAM22 recombinant protein
Organs/Tissues associated with ADAM22 recombinant protein
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