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ADAMTS1 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011313 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) ADAMTS1 recombinant protein
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1)

 Product Gene Name   

ADAMTS1 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) (MBS2001769)
Antigen: A Disintegrin And Metalloproteinase With Thrombospondin 1 (ADAMTS1) (MBS2011313)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-DLPGT LYDANRQCQF TFGEESTHCP DAASTCSTLW CTGTSGGLLV CQTKHFPWAD GTSCGEGKWC VSGKCVNKTD MKHFATPVHG SWGPWGPWGD CSRTCGGGVQ YTMRECDNPV PKNGGKYCEG KRVRYRSCNI EDCP
 Chromosome Location    Chromosome: 11; NC_005110.3 (28966006..28974872, complement). Location: 11q11-q22
 3D Structure    ModBase 3D Structure for Q9WUQ1
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Rattus norvegicus (Rat)
 Expression System    Prokaryotic expression
 Residues    Asp476~Pro614 (Accession # Q9WUQ1) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ADAMTS1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ADAMTS1 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for ADAMTS1 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for ADAMTS1. It may not necessarily be applicable to this product.
 NCBI GI #    11131014
 NCBI GeneID    79252
 NCBI Accession #    Q9WUQ1.1 [Other Products]
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 UniProt Primary Accession #    Q9WUQ1 [Other Products]
 UniProt Secondary Accession #    Q9ERI1 [Other Products]
 UniProt Related Accession #    Q9WUQ1 [Other Products]
 Molecular Weight    16.7kDa
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 1
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 1
 NCBI Official Symbol    Adamts1 [Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1); a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 1
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    Adamts1 [Similar Products]
 UniProt Synonym Gene Names    ADAM-TS 1; ADAM-TS1; ADAMTS-1 [Similar Products]
 UniProt Entry Name    ATS1_RAT
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 NCBI Summary for ADAMTS1    disintegrin and metalloprotease that may be necessary for normal kidney morphology and function [RGD, Feb 2006]
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 UniProt Comments for ADAMTS1    Function: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity

By similarity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture

By similarity.

Catalytic activity: Cleaves aggrecan at the 1683-Glu-|-Leu-1684 site, within the chondroitin sulfate attachment domain.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subcellular location: Secreted › extracellular space › extracellular matrix

By similarity.

Induction: Down-regulated in endothelial cells derived from cirrhotic liver.

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Post-translational modification: The precursor is cleaved by a furin endopeptidase

By similarity.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion

By similarity.

Sequence similarities: Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.Contains 3 TSP type-1 domains.
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 Research Articles on ADAMTS1    1. A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) was detected by proteomics (the pro- region) in lymph only after LPS
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ADAMTS1 recombinant proteinOrgans/Tissues associated with ADAMTS1 recombinant protein
 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Organ/Tissue Name  Pubmed Publications
 Ovary Antibodies  >34 publications with ADAMTS1 and Ovary
 Connective Tissue Antibodies  >24 publications with ADAMTS1 and Connective Tissue
 Muscle Antibodies  >23 publications with ADAMTS1 and Muscle
 Kidney Antibodies  >23 publications with ADAMTS1 and Kidney
 Brain Antibodies  >18 publications with ADAMTS1 and Brain
 Lung Antibodies  >11 publications with ADAMTS1 and Lung
 Liver Antibodies  >9 publications with ADAMTS1 and Liver
 Colon Antibodies  >6 publications with ADAMTS1 and Colon
 Placenta Antibodies  >5 publications with ADAMTS1 and Placenta
 Adipose Tissue Antibodies  >4 publications with ADAMTS1 and Adipose Tissue
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