NP_780710.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12; ADAM-TS12; ADAM-TS 12; metalloprotease disintegrin 12; a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 12; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Synonym Gene Names
UniProt Entry Name
ATS12_MOUSE
UniProt Comments for ADAMTS12
ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; EC 3.4.24.-; Protease; Secreted; Secreted, signal peptide
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region
Molecular Function: peptidase activity; metallopeptidase activity; hydrolase activity; zinc ion binding; metal ion binding; metalloendopeptidase activity
Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process; proteolysis
Research Articles on ADAMTS12
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Diseases associated with ADAMTS12 recombinant protein
Organs/Tissues associated with ADAMTS12 recombinant protein
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