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ADAMTS12 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 12 Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2031794 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) ADAMTS12 recombinant protein
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 12 (ADAMTS12)

 Product Gene Name   

ADAMTS12 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 12 (MBS2027021)
Antigen: A Disintegrin And Metalloproteinase With Thrombospondin 12 (MBS2031794)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606184
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 Purity/Purification    >95%
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 Accurate Molecular Mass (KD)    20kDa
 Expression System    Prokaryotic expression
 Tag    N-terminal His-Tag
 Organism Species    Homo sapiens (Human)
 Fragment    Gln823~Pro997
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 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ADAMTS12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ADAMTS12 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for ADAMTS12. It may not necessarily be applicable to this product.
 NCBI GI #    51558724
 NCBI GeneID    81792
 NCBI Accession #    NP_112217.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_030955.2 [Other Products]
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 UniProt Secondary Accession #    Q6UWL3; A2RRN9; A5D6V6 [Other Products]
 UniProt Related Accession #    P58397 [Other Products]
 Molecular Weight    168,460 Da
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 12
 NCBI Official Symbol    ADAMTS12 [Similar Products]
 NCBI Official Synonym Symbols   
PRO4389
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 12
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 12
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS12 [Similar Products]
 UniProt Synonym Gene Names    ADAM-TS 12; ADAM-TS12; ADAMTS-12 [Similar Products]
 UniProt Entry Name    ATS12_HUMAN
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 NCBI Summary for ADAMTS12    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS12    ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 5q35

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: protein binding; zinc ion binding; metalloendopeptidase activity

Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process
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 Research Articles on ADAMTS12    1. ADAMTS-12 is a multifaced metalloproteinase in arthritis and inflammation [review]
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAMTS12 recombinant proteinPathways associated with ADAMTS12 recombinant protein
 Reference Product  PubMed Publications
 COMP recombinant protein  >6 publications with ADAMTS12 and COMP
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-glycosylation Of TSR Domain-containing Proteins Pathway antibodies  O-glycosylation Of TSR Domain-containing Proteins Pathway Diagram
 O-linked Glycosylation Pathway antibodies  O-linked Glycosylation Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
Diseases associated with ADAMTS12 recombinant proteinOrgans/Tissues associated with ADAMTS12 recombinant protein
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >5 publications with ADAMTS12 and Disease Models, Animal
 Inflammation Antibodies  >4 publications with ADAMTS12 and Inflammation
 Necrosis Antibodies  >4 publications with ADAMTS12 and Necrosis
 Mental Disorders Antibodies  >2 publications with ADAMTS12 and Mental Disorders
 Atherosclerosis Antibodies  >1 publications with ADAMTS12 and Atherosclerosis
 Arteriosclerosis Antibodies  >1 publications with ADAMTS12 and Arteriosclerosis
 Brain Diseases Antibodies  >1 publications with ADAMTS12 and Brain Diseases
 Breast Neoplasms Antibodies  >1 publications with ADAMTS12 and Breast Neoplasms
 Lung Neoplasms Antibodies  >1 publications with ADAMTS12 and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with ADAMTS12 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >7 publications with ADAMTS12 and Bone
 Connective Tissue Antibodies  >5 publications with ADAMTS12 and Connective Tissue
 Lung Antibodies  >3 publications with ADAMTS12 and Lung
 Intestine Antibodies  >1 publications with ADAMTS12 and Intestine
 Heart Antibodies  >1 publications with ADAMTS12 and Heart
 Ovary Antibodies  >1 publications with ADAMTS12 and Ovary
 Kidney Antibodies  >1 publications with ADAMTS12 and Kidney
 Testis Antibodies  >1 publications with ADAMTS12 and Testis
 Embryonic Tissue Antibodies  >1 publications with ADAMTS12 and Embryonic Tissue
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