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ADAMTS2 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2010506 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2)

 Product Gene Name   

ADAMTS2 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) (MBS2003250)
Antigen: A Disintegrin And Metalloproteinase With Thrombospondin 2 (ADAMTS2) (MBS2010506)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
 Chromosome Location    Chromosome: 7; AC_000164.1 (1956352..2165242). Location: chromosome: 7
 3D Structure    ModBase 3D Structure for P79331
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Bos taurus; Bovine (Cattle)
 Expression System    Prokaryotic expression
 Residues    Gln474~Pro610 (Accession # P79331) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ADAMTS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ADAMTS2 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for ADAMTS2 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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 SDS-PAGE of ADAMTS2 recombinant protein    ADAMTS2 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ADAMTS2. It may not necessarily be applicable to this product.
 NCBI GI #    27807141
 NCBI GeneID    282401
 NCBI Accession #    NP_777056.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174631.2 [Other Products]
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 UniProt Primary Accession #    P79331 [Other Products]
 UniProt Related Accession #    P79331 [Other Products]
 Molecular Weight    16.6kDa
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 2
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 2<
 NCBI Official Symbol    ADAMTS2 [Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 2; pNPI; PC I-NP; ADAM-TS2; ADAMTS-2; ADAM-TS 2; procollagen I N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 2
 UniProt Synonym Protein Names   
Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS2 [Similar Products]
 UniProt Synonym Gene Names    NPI; ADAM-TS 2; ADAM-TS2; ADAMTS-2; PC I-NP; pNPI [Similar Products]
 UniProt Entry Name    ATS2_BOVIN
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 UniProt Comments for ADAMTS2    Function: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis.

Catalytic activity: Cleaves the N-propeptide of collagen chain alpha-1(I) at Pro-|-Gln and of alpha-1(II) and alpha-2(I) at Ala-|-Gln.

Cofactor: Binds 1 zinc ion per subunit

By similarity.

Subunit structure: May belong to a multimeric complex. Binds specifically to collagen type XIV.

Subcellular location: Secreted › extracellular space › extracellular matrix

By similarity.

Tissue specificity: Enzymatic activity is detected at high level in all type I collagen-rich tissues such as skin, bones, tendons and aorta and at low level in brain and thymus. The mRNA levels were disproportionately high in heart, liver, retina and muscle.

Domain: The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.

Post-translational modification: The N-terminus is blocked.The precursor is cleaved by a furin endopeptidase

By similarity.Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion

By similarity.

Involvement in disease: Defects in ADAMTS2 are the cause of dermatosparaxis, a recessively inherited disorder characterized by severe skin fragility and biochemically by the presence in skin of procollagen incompletely processed at the N-terminus.

Sequence similarities: Contains 1 disintegrin domain.Contains 1 peptidase M12B domain.Contains 1 PLAC domain.Contains 4 TSP type-1 domains.

Caution: Has sometimes been referred to as ADAMTS3.
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 Research Articles on ADAMTS2    1. specific ADAMTS-2 domains cleave the aminopropeptide of fibrillar procollagens types I-III and V
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ADAMTS2 recombinant proteinDiseases associated with ADAMTS2 recombinant protein
 Products by Pathway  Pathway Diagram
 Collagen Biosynthesis And Modifying Enzymes Pathway antibodies  Collagen Biosynthesis And Modifying Enzymes Pathway Diagram
 Collagen Formation Pathway antibodies  Collagen Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with ADAMTS2 and Neoplasms
 Inflammation Antibodies  >2 publications with ADAMTS2 and Inflammation
 Carcinoma Antibodies  >2 publications with ADAMTS2 and Carcinoma
 Nervous System Diseases Antibodies  >2 publications with ADAMTS2 and Nervous System Diseases
 Breast Neoplasms Antibodies  >1 publications with ADAMTS2 and Breast Neoplasms
 Liver Cirrhosis, Experimental Antibodies  >1 publications with ADAMTS2 and Liver Cirrhosis, Experimental
 Hyperplasia Antibodies  >1 publications with ADAMTS2 and Hyperplasia
 Precancerous Conditions Antibodies  >1 publications with ADAMTS2 and Precancerous Conditions
 Liver Diseases Antibodies  >1 publications with ADAMTS2 and Liver Diseases
 Necrosis Antibodies  >1 publications with ADAMTS2 and Necrosis
Organs/Tissues associated with ADAMTS2 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >9 publications with ADAMTS2 and Skin
 Muscle Antibodies  >1 publications with ADAMTS2 and Muscle
 Intestine Antibodies  >1 publications with ADAMTS2 and Intestine
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