NP_783574.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
Molecular Weight
Predicted Molecular Mass: 21.2kDa Accurate Molecular Mass: 22kDa as determined by SDS-PAGE reducing conditions.
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 2 isoform 1 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2
NCBI Official Synonym Symbols
pNPI; PCINP; hPCPNI; ADAM-TS2; ADAMTS-2; ADAMTS-3; mKIAA4060 [Similar Products]
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 2; PC I-NP; ADAM-TS 2; procollagen N-proteinase; procollagen N-endopeptidase; procollagen I/II amino propeptide-processing enzyme; a disintegrin and metalloproteinase with thrombospondin repeats; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 2
UniProt Synonym Protein Names
Procollagen I N-proteinase; PC I-NP; Procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase
UniProt Synonym Gene Names
UniProt Entry Name
ATS2_MOUSE
NCBI Summary for ADAMTS2
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin repeats) family of proteinases that is involved in the proteolytic processing of procollagens. The encoded protein precursor is proteolytically processed to generate a mature, zinc-dependent enzyme. Mice lacking the encoded protein develop abnormal lungs, fragile skin and male sterility. [provided by RefSeq, Aug 2015]
UniProt Comments for ADAMTS2
ADAMTS2: Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. May also play a role in development that is independent of its role in collagen biosynthesis. Defects in ADAMTS2 are the cause of Ehlers-Danlos syndrome type 7C (EDS7C). EDS is a connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity. EDS7C is marked by extremely fragile tissues, hyperextensible skin and easy bruising. Facial skin contains numerous folds, as in the cutis laxa syndrome. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 3.4.24.14; Secreted; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide; Extracellular matrix
Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular region
Molecular Function: peptidase activity; hydrolase activity; zinc ion binding; metallopeptidase activity; metal ion binding; metalloendopeptidase activity
Biological Process: skin development; collagen catabolic process; collagen fibril organization; protein processing; spermatogenesis; proteolysis; lung development
Research Articles on ADAMTS2
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Pathways associated with ADAMTS2 recombinant protein
Diseases associated with ADAMTS2 recombinant protein
Organs/Tissues associated with ADAMTS2 recombinant protein
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