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ADAMTS4 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2009500 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) ADAMTS4 recombinant protein
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $250 +1 FREE 8GB USB
0.1 mg  /  $385 +1 FREE 8GB USB
0.2 mg  /  $470 +1 FREE 8GB USB
0.5 mg  /  $910 +1 FREE 8GB USB
1 mg  /  $1,345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4)

 Product Gene Name   

ADAMTS4 recombinant protein

[Similar Products]
 Matching Pairs    Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) Clone #1# (MBS2001335)
Antigen: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) (MBS2009500)
 Matching Pairs    Antibody: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) (MBS2004212)
Antigen: A Disintegrin And Metalloproteinase With Thrombospondin 4 (ADAMTS4) (MBS2009500)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Sequence    The target protein is fused with N-terminal His-Tag, its sequence is listed below.
MGHHHHHHSG SEF-TFPG KDYDADRQCQ LTFGPDSRHC PQLPPPCAAL WCSGHLNGHA MCQTKHSPWA DGTPCGPAQA CMGGRCLHMD QLQDFNIPQA GGWGPWGPWG DCSRTCGGGV QFSSRDCTRP VPRNGGKYCE GRRTRFRSCN TEDCP
 Chromosome Location    Chromosome: 1; NC_000001.10 (161159538..161168845, complement). Location: 1q21-q23
 OMIM    603876
 3D Structure    ModBase 3D Structure for O75173
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 Host    E Coli
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 Purity/Purification    > 95%
 Form/Format    Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
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 Organism    Homo sapiens (Human)
 Expression System    Prokaryotic expression
 Residues    Thr437~Pro575 (Accession # O75173) with N-terminal His-Tag
 Endotoxin Level    <1.0EU per 1ug (determined by the LAL method)
 Reconstitution    Reconstitute in sterile PBS, pH7.2-pH7.4.
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 Preparation and Storage    Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ADAMTS4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ADAMTS4 recombinant protein

   About the Marker: Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at doubleintensity to make location and size approximation of proteins of interestquick and easy.
Ready-to-use: No need to heat, dilute or add reducing agents before use.
 Applications Tested/Suitable for ADAMTS4 recombinant protein   

SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

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NCBI/Uniprot data below describe general gene information for ADAMTS4. It may not necessarily be applicable to this product.
 NCBI GI #    157427675
 NCBI GeneID    9507
 NCBI Accession #    NP_005090.3 [Other Products]
 NCBI GenBank Nucleotide #    NM_005099.4 [Other Products]
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 UniProt Primary Accession #    O75173 [Other Products]
 UniProt Secondary Accession #    Q5VTW2; Q6P4Q8; Q6UWA8; Q9UN83 [Other Products]
 UniProt Related Accession #    O75173 [Other Products]
 Molecular Weight    16.7kDa
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 4
 NCBI Official Symbol    ADAMTS4 [Similar Products]
 NCBI Official Synonym Symbols   
ADMP-1; ADAMTS-2; ADAMTS-4
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 4
 UniProt Synonym Protein Names   
ADMP-1; Aggrecanase-1
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS4 [Similar Products]
 UniProt Synonym Gene Names    KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4 [Similar Products]
 UniProt Entry Name    ATS4_HUMAN
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 NCBI Summary for ADAMTS4    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS4    ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Secreted; Secreted, signal peptide; EC 3.4.24.82; Protease; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development
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 Research Articles on ADAMTS4    1. ADAMTS-4_v1 is expressed as a protein in vivo in human osteoarthritis synovium, functions as an aggrecanase, and cleaves other proteoglycan substrates.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAMTS4 recombinant proteinPathways associated with ADAMTS4 recombinant protein
 Reference Product  PubMed Publications
 BCAN recombinant protein  >9 publications with ADAMTS4 and BCAN
 ACAN recombinant protein  >8 publications with ADAMTS4 and ACAN
 TGFB1 recombinant protein  >3 publications with ADAMTS4 and TGFB1
 FURIN recombinant protein  >3 publications with ADAMTS4 and FURIN
 OSM recombinant protein  >2 publications with ADAMTS4 and OSM
 IL1B recombinant protein  >2 publications with ADAMTS4 and IL1B
 IL17A recombinant protein  >1 publications with ADAMTS4 and IL17A
 SRPX2 recombinant protein  >1 publications with ADAMTS4 and SRPX2
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
Diseases associated with ADAMTS4 recombinant proteinOrgans/Tissues associated with ADAMTS4 recombinant protein
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >17 publications with ADAMTS4 and Inflammation
 Necrosis Antibodies  >15 publications with ADAMTS4 and Necrosis
 Neoplasms Antibodies  >14 publications with ADAMTS4 and Neoplasms
 Nervous System Diseases Antibodies  >7 publications with ADAMTS4 and Nervous System Diseases
 Arthritis, Rheumatoid Antibodies  >7 publications with ADAMTS4 and Arthritis, Rheumatoid
 Brain Diseases Antibodies  >6 publications with ADAMTS4 and Brain Diseases
 Atherosclerosis Antibodies  >5 publications with ADAMTS4 and Atherosclerosis
 Heart Diseases Antibodies  >4 publications with ADAMTS4 and Heart Diseases
 Myocardial Infarction Antibodies  >4 publications with ADAMTS4 and Myocardial Infarction
 Weight Loss Antibodies  >2 publications with ADAMTS4 and Weight Loss
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with ADAMTS4 and Brain
 Muscle Antibodies  >5 publications with ADAMTS4 and Muscle
 Embryonic Tissue Antibodies  >3 publications with ADAMTS4 and Embryonic Tissue
 Lung Antibodies  >1 publications with ADAMTS4 and Lung
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