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ADAMTS8 recombinant protein :: A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8) Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS2011305 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $140 +1 FREE 8GB USB
0.05 mg  /  $260 +1 FREE 8GB USB
0.1 mg  /  $400 +1 FREE 8GB USB
0.2 mg  /  $495 +1 FREE 8GB USB
0.5 mg  /  $955 +1 FREE 8GB USB
1 mg  /  $1,415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant A Disintegrin And Metalloproteinase With Thrombospondin 8 (ADAMTS8)

 Product Gene Name   

ADAMTS8 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (130274660..130298539, complement). Location: 11q25
 OMIM    605175
 3D Structure    ModBase 3D Structure for Q9UP79
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 Host    E Coli
 Species Reactivity    Human
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 Purity/Purification    > 95%
 Form/Format    PBS, pH7.4, containing 1mM DTT, 5% trehalose, 0.01% sarcosyl and Proclin300.
 Concentration    200ug/mL (lot specific)
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 Source    Prokaryotic expression
 Residues    Leu832~Leu889
 Tags    N-terminal His-Tag
 Tissue Specificity    Lung
 Subcellular Location    Secreted, extracellular space, extracellular matrix
 Traits    Freeze-dried powder
 Predicted isoelectric point    6.3
 Predicted Molecular Mass    7.6kDa
 Accurate Molecular Mass    13kDa as determined by SDS-PAGE reducing conditions
 Usage    Reconstitute in PBS (pH7.4) to a concentration of 0.1-1.0 mg/mL. Do not vortex
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 Preparation and Storage    Storage: Avoid repeated freeze/thaw cycles.Store at 2-8 degree C for one month.Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed.The loss rate is less than 5% within the expiration date under appropriate storage condition
 ISO Certification    Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
 Supply Chain Verification    Manufactured in an a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of ADAMTS8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for ADAMTS8 recombinant protein   

SDS-PAGE, WB, ELISA, IP, CoIP, Purification, Amine Reactive Labeling.
(May be suitable for use in other assays to be determined by the end user.)

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 Sequence of ADAMTS8 recombinant protein    ADAMTS8 recombinant protein Sequence image
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 Gene Sequencing of ADAMTS8 recombinant protein    ADAMTS8 recombinant protein Gene Sequencing image
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 SDS-PAGE of ADAMTS8 recombinant protein    ADAMTS8 recombinant protein SDS-PAGE image
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NCBI/Uniprot data below describe general gene information for ADAMTS8. It may not necessarily be applicable to this product.
 NCBI GI #    153792351
 NCBI GeneID    11095
 NCBI Accession #    NP_008968.4 [Other Products]
 NCBI GenBank Nucleotide #    NM_007037.4 [Other Products]
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 UniProt Primary Accession #    Q9UP79 [Other Products]
 UniProt Secondary Accession #    Q9NZS0 [Other Products]
 UniProt Related Accession #    Q9UP79 [Other Products]
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 NCBI Official Full Name    A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase with thrombospondin type 1 motif, 8
 NCBI Official Symbol    ADAMTS8 [Similar Products]
 NCBI Official Synonym Symbols   
METH2; ADAM-TS8
[Similar Products]
 NCBI Protein Information    A disintegrin and metalloproteinase with thrombospondin motifs 8; METH-2; METH-8; ADAMTS-8; ADAM-TS 8; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8
 UniProt Protein Name    A disintegrin and metalloproteinase with thrombospondin motifs 8
 UniProt Synonym Protein Names   
METH-2; METH-8
 Protein Family    A disintegrin and metalloproteinase with thrombospondin motifs
 UniProt Gene Name    ADAMTS8 [Similar Products]
 UniProt Synonym Gene Names    METH2; ADAM-TS 8; ADAM-TS8; ADAMTS-8 [Similar Products]
 UniProt Entry Name    ATS8_HUMAN
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 NCBI Summary for ADAMTS8    This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ADAMTS8    ADAMTS8: Has anti-angiogenic properties.

Protein type: EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Protease; Secreted, signal peptide; Cell cycle regulation

Chromosomal Location of Human Ortholog: 11q25

Cellular Component: extracellular matrix; proteinaceous extracellular matrix

Molecular Function: heparin binding; integrin binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity; low affinity phosphate transmembrane transporter activity

Biological Process: negative regulation of cell proliferation; proteolysis
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 Research Articles on ADAMTS8    1. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with ADAMTS8 recombinant proteinDiseases associated with ADAMTS8 recombinant protein
 Products by Pathway  Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >3 publications with ADAMTS8 and Adenocarcinoma
 Disease Models, Animal Antibodies  >3 publications with ADAMTS8 and Disease Models, Animal
 Brain Diseases Antibodies  >2 publications with ADAMTS8 and Brain Diseases
 Myocardial Infarction Antibodies  >1 publications with ADAMTS8 and Myocardial Infarction
 Liver Diseases Antibodies  >1 publications with ADAMTS8 and Liver Diseases
 Hypertension Antibodies  >1 publications with ADAMTS8 and Hypertension
Organs/Tissues associated with ADAMTS8 recombinant protein
 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >2 publications with ADAMTS8 and Heart
 Brain Antibodies  >2 publications with ADAMTS8 and Brain
 Lung Antibodies  >2 publications with ADAMTS8 and Lung
 Connective Tissue Antibodies  >1 publications with ADAMTS8 and Connective Tissue
 Pancreas Antibodies  >1 publications with ADAMTS8 and Pancreas
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