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ADAM12 recombinant protein :: A Disintegrin and Metalloproteinase Domain 12 S Isoform Recombinant Protein

Scan QR to view Datasheet Catalog #    MBS143543 ADAM12 recombinant protein
Unit / Price
0.002 mg  /  $140 +1 FREE 8GB USB
0.01 mg  /  $205 +1 FREE 8GB USB
1 mg  /  $4,665 +5 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

A Disintegrin and Metalloproteinase Domain 12 S Isoform (ADAM12), Recombinant Protein

★Popular Item★
 Also Known As   

Recombinant Human A Disintegrin and Metalloproteinase Domain 12 S Isoform

 Product Synonym Names    ADAM12 Human; A Disintegrin and Metalloproteinase Domain 12 S-Isoform Human Recombinant; Meltrin alpha; MCMP; MLTN; MLTNA; MCMPMltna; ADAM metallopeptidase domain 12; ADAM 12; ADAM12
 Product Gene Name   

ADAM12 recombinant protein

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602714
 3D Structure    ModBase 3D Structure for O43184
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 Host    E Coli
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 Purity/Purification    Greater than 95.0% as determined by SDS-PAGE.
 Form/Format    The ADAM12 solution contains 20mM Tris-HCl and 50% Glycerol.
Sterile Filtered colorless solution.
 Concentration    0.126 mg/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
 Other Notes    Small volumes of ADAM12 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for ADAM12 recombinant protein

   Description: ADAM12 Short/soluble isoform Human Recombinant fused to N-terminal His-Tag produced in E Coli is a single, non-glycosylated polypeptide chain containing 531 amino acids (208-738) and having a molecular mass of 62 kDa.

Introduction: ADAM12 is part of the A Disintegrin and Metalloprotease protein family wjich are membrane-anchored proteins structurally related to snake venom disintegrins, and are involved in a range of biological processes concerning cell-cell and cell-matrix interactions, including fertilization, muscle development, and eurogenesis. ADAM12 has 2 alternatively spliced transcripts, a shorter/soluble secreted form called S-isoform and a longer membrane-bound form call L isoform. The S isoform is found to stimulate myogenesis. The short & soluble isoform lacks the transmembrane and cytoplasmic domains. ADAM12 S Isoform expression is limited to the placenta, embryo and foetus although levels have been detected in some tumour cell lines. ADAM12 takes part in skeletal muscle regeneration, specifically at the onset of cell fusion. ADAM12 is involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (by similarity).
 Product Categories/Family for ADAM12 recombinant protein    RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; A Disintegrin and Metalloproteinase Domain
NCBI/Uniprot data below describe general gene information for ADAM12. It may not necessarily be applicable to this product.
 NCBI GI #    572882491
 NCBI GeneID    8038
 NCBI Accession #    NP_001275903.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001288974.1 [Other Products]
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 UniProt Primary Accession #    O43184 [Other Products]
 UniProt Secondary Accession #    O60470; Q5JRP0; Q5JRP1; Q6P9E3; Q6UWB0 [Other Products]
 UniProt Related Accession #    O43184 [Other Products]
 Molecular Weight    80,263 Da
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 NCBI Official Full Name    disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein
 NCBI Official Synonym Full Names    ADAM metallopeptidase domain 12
 NCBI Official Symbol    ADAM12 [Similar Products]
 NCBI Official Synonym Symbols   
MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1
[Similar Products]
 NCBI Protein Information    disintegrin and metalloproteinase domain-containing protein 12; meltrin-alpha; metalloprotease-disintegrin 12 transmembrane
 UniProt Protein Name    Disintegrin and metalloproteinase domain-containing protein 12
 UniProt Synonym Protein Names   
Meltrin-alpha
 Protein Family    Disintegrin and metalloproteinase domain-containing protein
 UniProt Gene Name    ADAM12 [Similar Products]
 UniProt Synonym Gene Names    MLTN; ADAM 12 [Similar Products]
 UniProt Entry Name    ADA12_HUMAN
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 NCBI Summary for ADAM12    This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
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 UniProt Comments for ADAM12    ADAM12: contains a disintegrin and metalloprotease (ADAM) domain 12, which is a member of the ADAM protein family. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion, and the differentiation of macrophage-derived giant cells (MGC) and osteoclasts. 2 alternative splicing isoforms have been described: a shorter secreted form and a longer membrane-bound form. The shorter form stimulates myogenesis.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; EC 3.4.24.-; Protease

Chromosomal Location of Human Ortholog: 10q26

Cellular Component: nucleoplasm; mitochondrion; plasma membrane; integral to membrane; extracellular region

Molecular Function: protein binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity; SH3 domain binding

Biological Process: epidermal growth factor receptor signaling pathway; cell adhesion; proteolysis; myoblast fusion
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 Research Articles on ADAM12    1. Data confirms activity of trophoblast-derived ADAM12S by demonstrating its potential to degrade insulin-like growth factor-binding protein 3. ADAM12S exerts pro-migratory function in trophoblasts by inducing integrin beta 1-mediated cellular spreading.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with ADAM12 recombinant proteinPathways associated with ADAM12 recombinant protein
 Reference Product  PubMed Publications
 ADAM17 recombinant protein  >27 publications with ADAM12 and ADAM17
 ADAM10 recombinant protein  >25 publications with ADAM12 and ADAM10
 EGF recombinant protein  >25 publications with ADAM12 and EGF
 EGFR recombinant protein  >13 publications with ADAM12 and EGFR
 DLL1 recombinant protein  >2 publications with ADAM12 and DLL1
 IGFBP3 recombinant protein  >2 publications with ADAM12 and IGFBP3
 ITGB1 recombinant protein  >1 publications with ADAM12 and ITGB1
 SH3D19 recombinant protein  >1 publications with ADAM12 and SH3D19
 PACSIN3 recombinant protein  >1 publications with ADAM12 and PACSIN3
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By EGFR Pathway antibodies  Signaling By EGFR Pathway Diagram
 Signaling By EGFR In Cancer Pathway antibodies  Signaling By EGFR In Cancer Pathway Diagram
 Signaling By EGFRvIII In Cancer Pathway antibodies  Signaling By EGFRvIII In Cancer Pathway Diagram
 Signaling By Ligand-Responsive EGFR Variants In Cancer Pathway antibodies  Signaling By Ligand-Responsive EGFR Variants In Cancer Pathway Diagram
 Signaling By Overexpressed Wild-Type EGFR In Cancer Pathway antibodies  Signaling By Overexpressed Wild-Type EGFR In Cancer Pathway Diagram
 Syndecan-4-mediated Signaling Events Pathway antibodies  Syndecan-4-mediated Signaling Events Pathway Diagram
Diseases associated with ADAM12 recombinant proteinOrgans/Tissues associated with ADAM12 recombinant protein
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >24 publications with ADAM12 and Necrosis
 Breast Neoplasms Antibodies  >22 publications with ADAM12 and Breast Neoplasms
 Hypertension Antibodies  >13 publications with ADAM12 and Hypertension
 Fibrosis Antibodies  >12 publications with ADAM12 and Fibrosis
 Disease Models, Animal Antibodies  >9 publications with ADAM12 and Disease Models, Animal
 Lung Neoplasms Antibodies  >9 publications with ADAM12 and Lung Neoplasms
 Inflammation Antibodies  >9 publications with ADAM12 and Inflammation
 Cardiomegaly Antibodies  >7 publications with ADAM12 and Cardiomegaly
 Hypertrophy Antibodies  >7 publications with ADAM12 and Hypertrophy
 Carcinoma, Hepatocellular Antibodies  >4 publications with ADAM12 and Carcinoma, Hepatocellular
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >56 publications with ADAM12 and Muscle
 Placenta Antibodies  >29 publications with ADAM12 and Placenta
 Vascular Antibodies  >27 publications with ADAM12 and Vascular
 Bone Antibodies  >24 publications with ADAM12 and Bone
 Embryonic Tissue Antibodies  >22 publications with ADAM12 and Embryonic Tissue
 Brain Antibodies  >15 publications with ADAM12 and Brain
 Lung Antibodies  >14 publications with ADAM12 and Lung
 Heart Antibodies  >12 publications with ADAM12 and Heart
 Liver Antibodies  >12 publications with ADAM12 and Liver
 Connective Tissue Antibodies  >12 publications with ADAM12 and Connective Tissue
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