P11200.3
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UniProt Primary Accession #
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UniProt Secondary Accession #
NCBI Official Full Name
Outer capsid protein VP4
UniProt Protein Name
Outer capsid protein VP4
UniProt Synonym Protein Names
Hemagglutinin
UniProt Comments for VP4
Spike-forming protein that mediates virion attachment to the host epithelial cell receptors and plays a major role in cell penetration, determination of host range restriction and virulence. Rotavirus entry into the host cell probably involves multiple sequential contacts between the outer capsid proteins VP4 and VP7, and the cell receptors. According to the considered strain, VP4 seems to essentially target sialic acid and/or the integrin heterodimer ITGA2/ITGB1 ().
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