NP_780710.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
18,843 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein
NCBI Official Synonym Full Names
a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 12
UniProt Synonym Gene Names
NCBI Summary for Adamts12
This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active protease. Mice lacking the encoded protein exhibit increased angiogenic response and tumor invasion in different models of angiogenesis and, severe inflammation and delayed recovery when subjected to experimental conditions that induce colitis, endotoxic sepsis and pancreatitis. [provided by RefSeq, Jul 2016]
UniProt Comments for Adamts12
Metalloprotease that plays a role in the degradation of COMP (). Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties ().
Research Articles on Adamts12
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Products associated with Adamts12 recombinant protein
Diseases associated with Adamts12 recombinant protein
Organs/Tissues associated with Adamts12 recombinant protein
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