NP_008968.4
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
96,460 Da
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 8 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif 8
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 8
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 8
UniProt Synonym Protein Names
METH-2; METH-8
UniProt Synonym Gene Names
NCBI Summary for ADAMTS8
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs, and disrupts angiogenesis in vivo. A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms. Reduced expression of this gene has been observed in multiple human cancers and this gene has been proposed as a potential tumor suppressor. [provided by RefSeq, Feb 2016]
UniProt Comments for ADAMTS8
Has anti-angiogenic properties.
Research Articles on ADAMTS8
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Pathways associated with ADAMTS8 recombinant protein
Diseases associated with ADAMTS8 recombinant protein
Organs/Tissues associated with ADAMTS8 recombinant protein
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